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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Renal resilience represents the functional reserve capacity of the kidneys, which becomes measurable following unilateral nephrectomy as change in single-kidney glomerular filtration rate (ΔskGFR). While the causes and consequences of inter-individual differences in renal resilience are incompletely understood, dysregulation of metabolic processes is conceivably involved. The aim of this research was to investigate whether plasma ketone bodies, as potential markers of lipid and energy metabolism, are associated with renal resilience in living kidney donors.
A total of 167 living kidney donors from the TransplantLines Biobank and Cohort Study (Groningen, the Netherlands) were included. Measured GFR (mGFR) was determined pre- and 3 months post-donation using 125I-iothalamate. ΔskGFR, representing renal resilience, was calculated using the following formula: post-donation mGFR - (pre-donation mGFR/2). Blood levels of total ketone bodies and their subspecies, namely beta-hydroxybutryate (BHB), acetoacetate, and acetone, were quantified through nuclear magnetic resonance spectroscopy. The association between renal resilience and ketone bodies was assessed by multivariate linear regression, adjusted for potential confounders.
Median (interquartile range, IQR) donor age was 55 (49-64) years, and 47% were females. Pre-donation mGFR was 108 (95 – 122) mL/min, and ΔskGFR was 15.1 (10.6 – 21.0) mL/min. The median plasma ketone bodies (total) concentration was 152.6 (119.0 – 196.5) μmol/L. In crude analysis, ketone bodies were negatively associated with ΔskGFR (standardized β, -0.16 [95% confidence interval, CI, -0.31 to -0.01], p=0.04). In a fully adjusted model (age, sex, pre-donation mGFR, glucose and HbA1c), this association remained significant (standardized β, -0.15 [95% CI -0.30 to -0.003], p=0.046). To investigate which subspecies of ketone bodies drove this association, we subsequently explored the association between renal resilience and ketone body subspecies. In the fully adjusted models, no significant association was found for acetoacetate (standardized β, -0.12 [95% CI -0.27 to 0.03], p=0.12) or for acetone (standardized β, -0.13 [95% CI -0.29 to 0.01], p=0.07), while there was a robust negative association between BHB and ΔskGFR (standardized β, -0.16 [95% CI -0.31 to -0.007], p=0.04).
Higher pre-donation plasma levels of ketone bodies are associated with lower renal resilience (ΔskGFR), independent of potential confounders. These results signify the potential role of early metabolic dysregulation in decreased renal resilience, possibly providing novel kidney-protective therapeutic intervention strategies.
