NEW EQUATION FOR ESTIMATING GLOMERULAR FILTRATION RATE IN VIETNAMESE KIDNEY TRANSPLANT RECIPIENTS

 

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https://storage.unitedwebnetwork.com/files/1099/dfba8b285ab19f6a6483006fe125dc13.pdf
NEW EQUATION FOR ESTIMATING GLOMERULAR FILTRATION RATE IN VIETNAMESE KIDNEY TRANSPLANT RECIPIENTS

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Thi Tram Anh
Bui
Bao An Huynh hbanctump@gmail.com Can Tho University of Medicine and Pharmacy Faculty of Medicine Can Tho Vietnam -
Nguyen Huy Hoang Ho huyhoang061203@gmail.com Can Tho University of Medicine and Pharmacy Faculty of Medicine Can Tho Vietnam -
Thi Tram Anh Bui bttanhctump@gmail.com Can Tho University of Medicine and Pharmacy Faculty of Medicine Can Tho Vietnam *
Khac Chuan Hoang hoangkhacchuan@gmail.com Cho Ray Hospital Department of Urology Ho Chi Minh Vietnam -
Thai Thanh Tam Tran ttttam@ctump.edu.vn Can Tho University of Medicine and Pharmacy Department of Physiology, Faculty of Medicine Can Tho Vietnam -
 
 
 
 
 
 
 
 
 
 

Accurate assessment of kidney function is essential for post-kidney transplant management. This study aims to develop a new equation tailored to Vietnamese kidney transplant recipients and validate its performance against established equations.

A total of 299 kidney transplant recipients underwent glomerular fltration rate (GFR) measurement using technetium-99m-diethylenetriaminepentaacetate renal dynamic scintigraphy, along with demographic, clinical, and laboratory assessments. Participants were divided into a development cohort (n = 150) to generate a new GFR-estimating equation and a validation cohort (n = 149) for internal validation against six equations.

The new equation, GFR = 100.430 × 1.080^sex × age^(−0.097) × Scr^(−0.524) × Scys^(−0.435) (sex: 0 = female; 1 = male), showed the smallest median bias (–0.11 [–1.40; 1.11]), highest P30 accuracy (94.0% [88.6; 96.6]), highest precision (interquartile range = 9.82 [7.63; 12.37]), and strongest correlation with measured GFR (r= 0.824 [0.752; 0.880]) among tested equations in the validation cohort. Among creatinine-based equations, the Modifcation of Diet in Renal Disease equation was the most accurate.


 


The new equation outperformed established equations and is recommended for Vietnamese kidney transplant recipients. The Modifcation of Diet in Renal Disease equation may serve as an alternative in centers lacking access to serum cystatin C. Further studies with larger cohorts, external validation, and comparisons with gold-standard GFR measurement methods are needed to confrm these results.
This abstract is submitted as an encore presentation. The full study has been previously published. (Huynh, B. A., Ho, N. H. H., Bui, T. T. A., Hoang, K. C., & Tran, T. T. T. (2025). New equation for estimating glomerular filtration rate in Vietnamese kidney transplant recipients. International urology and nephrology, 57(8), 2657–2667. https://doi.org/10.1007/s11255-025-04458-6)

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