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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
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E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
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Abstract titles should be brief and reflect the content of the abstract.
Tenofovir Disoproxil Fumarate (TDF), a crucial antiretroviral for HIV/AIDS and hepatitis B, is a nephrotoxic drug and also induces cardiovascular dysfunction through oxidative stress and mitochondrial damage in renal tubules, leading to acute kidney injury (AKI) in 10-30% of patients. Although these adverse effects are well-documented, protective strategies remain underexplored. Physical exercise emerges as a promising approach, with renoprotective and vascular benefits.Objective: The objective of this study was to evaluate whether moderate exercise can attenuate TDF-induced nephrotoxicity in rats.
Renal function was evaluated by inulin clearance (Clin), Neutrophil gelatinase-associated-lipocalin (NGAL) and serum creatinine. The oxidative profile was evaluated by urinary peroxides (FOX), lipid peroxides (TBARS), thiols and catalase.Adult Wistar rats(n=28) were divided into four groups (n=7/group):Control(C): Received vehicle treatment.TDF: Received TDF(600 mg/kg via gavage for 5 days).Physical Training(PT) group:Underwent swimming training (60 minutes daily, 5 days/week, with 5% body weight attached to the tail) until the 28th day.PT+TDF: Received both TDF treatment and physical training as described. On the 29th day, the animals were euthanized under 5% isoflurane anesthesia, followed by exploratory laparotomy for blood and tissue collection
Results(mean±SD; *p≤0.05, t-test):Renal Function Analyzed: Neutrophil gelatinase-associated-lipocalin(NGAL), Inulin clearance (Inu), NGAL levels(ng/mL):C: (4.7±0.2),TDF:(10.3±4.1*),PT:(5.8±0.3),PT+TDF:( 6.6±1.7*).Inulin clearance (mL/min):C(0.8±0.1),TDF:(0.3 ± 0.08*),PT:(0.7 ± 0.11),PT+TDF:(0.4 ±0.09*).Oxidative Stress Markers: Increased urinary lipid peroxidation (TBARS,nM/g): C:(0.3 ± 0.08),TDF:(0.73 ± 0.2*),PT:(0.2 ± 0.05), PT +TDF:(0.22 ± 0.08)*, Reduced thiol levels (nmol/g of total protein): C:(23.9± 2.08), TDF:(3.56 ± 0.9*), PT:(22.98±6.07), PT+TDF:(27.9±8.01*),Animals subjected to exercise showed improved tubular function PT+TDF(NGAL: 6.6±1.7),and glomerular function PT+TDF(Inu:0.4±0.09), Oxidative stress showed significant improvement as evidenced by PT+TDF (TBARS:0.22±0.08), enhanced thiol levels PT+TDF(27.9±8.01)Physical exercise applied to the TDF animals increased inulin clearance and reduced urinary Ngal. Regarding hemodynamic parameters, the animals receiving TDF showed an increase in mean arterial pressure, whereas those that swam exhibited a reduction in arterial pressure, decreased renal vascular resistance and enhanced renal blood flow.
TDF treatment impaired blood pressure, renal blood flow, renal function and increased oxidative stress. Moderate physical training showed renoprotective effects, improving tubular function and reducing oxidative damage and hemodynamic profile. Our findings demonstrate that moderate physical attenuate TDF nephrotoxicity, suggesting that exercise can act as an effective non-pharmacological strategy for renal protection in individuals undergoing TDF therapy. Further studies are needed to assess long-term outcomes.
