RECURRENT SECONDARY HYPERPARATHYROIDISM ELEVEN YEARS LATER DUE TO IMAGING-NEGATIVE ECTOPIC PARATRACHEAL PARATHYROID GLAND

 

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https://storage.unitedwebnetwork.com/files/1099/f08c94083cc5330d265482d4d8fca656.pdf
RECURRENT SECONDARY HYPERPARATHYROIDISM ELEVEN YEARS LATER DUE TO IMAGING-NEGATIVE ECTOPIC PARATRACHEAL PARATHYROID GLAND

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SUNG-LIN
HSIEH
SUNG-LIN HSIEH 034897@tool.caaumed.org.tw China Medical University Hospital Nephrology Taichung Taiwan *
WEN-YUN CHENG 100900@tool.caaumed.org.tw China Medical University Hospital Department of Nursing Taichung Taiwan -
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Despite advancements in imaging and surgical techniques, persistent or recurrent secondary hyperparathyroidism (SHPT) remains relatively common. The primary objective of preoperative imaging is to identify all sources of excess parathyroid hormone secretion. However, physiologic parathyroid glands—typically small, approximately 5 × 3 × 1 mm—are often difficult to visualize. With increasing life expectancy, we hypothesize that postoperative imaging follow-up to detect residual physiologic parathyroid glands, previously missed on imaging, is essential for the long-term management of hemodialysis (HD) patients.

We report a 46-year-old woman with stage 5 chronic kidney disease for 10 years, followed by another 10 years of long-term hemodialysis. She developed recurrent secondary hyperparathyroidism 11 years after undergoing subtotal parathyroidectomy, attributed to a Technetium 99m sestamibi single photon emission computed tomography and computed tomography (Tc-99m-MIBI SPECT/CT)-negative ectopic paratracheal parathyroid gland.

During the pre-dialysis period, one year before hemodialysis started, she underwent subtotal parathyroidectomy to remove the enlarged bilateral inferior parathyroid glands. No enlarged parathyroid glands were identified at the upper poles of the bilateral thyroid lobes during surgery. However, the preoperative Tc-99m-MIBI SPECT/CT failed to detect an ectopic paratracheal parathyroid gland (Figure 1, blue arrows), which caused recurrent secondary hyperparathyroidism (SHPT) eleven years later. On preoperative computed tomography (CT) scan, the ectopic paratracheal parathyroid gland appeared to be of normal size and resembled a typical lymph node (Figure 2, yellow arrow). This paratracheal parathyroid was revealed by repeated Tc-99m-MIBI SPECT/CT (Figure 3) and confirmed histologically via endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) (Figure 4). Due to the complexity of surgical intervention, the patient was started on calcimimetic therapy.Figure 1: Preoperative SPECT/CT failed to detect paratracheal parathyroid glandFigure 2: On preoperative CT scan, the ectopic paratracheal parathyroid gland appeared to be of normal size and resembled a typical lymph node.A repeated SPECT/CT scan performed 11 years later demonstrated radionuclide uptake at the hypertrophied ectopic paratracheal parathyroid gland.

While ectopic parathyroid adenomas were common in recurrent SHPT, physiologic uptake on initial 99mTc-MIBI SPECT/CT imaging did not indicate pathology. Therefore, repeat 99mTc-MIBI SPECT/CT imaging was essential for detection in our case.

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