LONG-TERM OUTCOMES OF NEPHROLOGIST FOLLOW-UP VERSUS USUAL CARE IN POST ACUTE KIDNEY INJURY SURVIVORS

 

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https://storage.unitedwebnetwork.com/files/1099/673d5e9c510cf23bd57a09d9c6adb609.pdf
LONG-TERM OUTCOMES OF NEPHROLOGIST FOLLOW-UP VERSUS USUAL CARE IN POST ACUTE KIDNEY INJURY SURVIVORS

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Patharasit
Jindapateep
Patharasit Jindapateep patharasit@hotmail.com Thammasat University Hospital Medicine Pathumthani Thailand *
Peerapat Thanapongsatorn peerapat.manu@gmail.com Thammasat University Hospital Medicine Pathumthani Thailand -
 
 
 
 
 
 
 
 
 
 
 
 
 

Acute kidney injury (AKI) is associated with significant short-term morbidity and mortality. However, survivors of AKI remain at risk for long-term adverse outcomes, including recurrent AKI, chronic kidney disease (CKD), end-stage kidney disease (ESKD), cardiovascular events, and increased mortality. Recurrent AKI contributes to progressive renal dysfunction, cardiovascular complications, and higher mortality. Despite these risks, post-AKI follow-up care remains inconsistent. This study aimed to evaluate the occurrence of recurrent AKI and other long-term outcomes among survivors of severe AKI, comparing those managed by nephrologists with those receiving usual care.

This retrospective cohort study was conducted at a tertiary care center in Thailand. Adult patients who survived hospitalization with AKI stage 2 or 3, as defined by KDIGO criteria, were included. Patients with end-stage kidney disease on dialysis, baseline eGFR <15 mL/min/1.73 m² (CKD-EPI 2021), kidney transplantation, or terminal illnesses with life expectancy <12 months were excluded. Baseline characteristics, comorbidities, causes of AKI, and laboratory data were collected and reviewed for one year after hospital discharge (August 2022–July 2024). To minimize confounding, propensity score matching (1:2 ratio, nearest-neighbor without replacement) was performed using covariates including CKD, AKI stage, renal recovery at discharge, and discharge serum creatinine.

A total of 440 AKI survivors were included, with 100 (22.7%) receiving nephrologist follow-up and 340 (77.3%) receiving usual care. After propensity score matching, 150 patients remained (nephrologist = 50, usual care = 100), with balanced baseline characteristics.

During follow-up, the incidence rate of recurrent AKI was 69.7 and 69.9 events per 100 person-years in the nephrologist and usual care groups, respectively (HR 0.98, 95% CI 0.70–1.38, p = 0.91). After matching, the rate tended to be lower among patients followed by nephrologists (63.9 vs 72.9 events per 100 person-years; HR 0.84, 95% CI 0.49–1.45, p = 0.54), although not statistically significant.

There were no significant differences in major adverse kidney events (MAKE), major adverse cardiovascular events (MACE), or mortality between groups before or after matching. However, nephrologist follow-up was associated with a higher frequency of UACR monitoring (46.0% vs 13.8%, p < 0.001) and a trend toward lower readmission rates after matching (67.9 vs 107.7 events per 100 person-years; HR 0.64, 95% CI 0.39–1.06, p = 0.085).

Incidence of recurrent AKI

Among survivors of severe AKI, follow-up by nephrologists was associated with a comparable incidence of recurrent AKI and major adverse outcomes compared with usual care. Although not statistically significant, nephrologist follow-up showed a trend toward lower readmission rates and was associated with substantially better adherence to kidney function monitoring. These findings highlight the potential value of structured nephrology follow-up in post-AKI care.

Kewords