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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Chronic kidney disease (CKD) is a major global health issue, affecting over 10% of adults worldwide and showing high prevalence in East Asia. However, the genetic architecture of CKD and related traits in East Asians has been less explored compared with Europeans. Because genetic associations can be ancestry-specific, studies in non-European populations are crucial for understanding disease biology and ensuring equitable application of genomic discoveries. We therefore investigated kidney-related traits in East Asians through large-scale genome-wide association study (GWAS) meta-analyses and further integrated the results with European data in a trans-ancestry meta-analysis.
We analyzed GWAS summary statistics for three traits: CKD (binary trait), estimated glomerular filtration rate (eGFR, continuous trait) calculated from serum creatinine level, and urinary albumin-to-creatinine ratio (UACR, continuous trait). Data came from eight East Asian cohorts: J-Kidney-Biobank (supported by Japanese Society of Nephrology), Tohoku Medical Megabank Organization, Biobank Japan, Iwate Tohoku Medical Megabank Organization, Japan Multi-Institutional Collaborative Cohort Study, Japan Prospective Studies Collaboration for Aging and Dementia (Japan), China Kadoorie Biobank (China), and KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (South Korea). Trait-specific meta-analyses were performed, and results were combined with European summary statistics (CKD: 625,219 individuals; eGFR: 1,464,866; albuminuria: 382,500), creating the largest international meta-GWAS of kidney traits to date.
Sample sizes in East Asians were: CKD, 340,993 individuals including 75,401 cases; eGFR, 240,401; and UACR, 50,984. Genome-wide significant loci were identified as follows: CKD, 1 novel/8 total; eGFR, 2 novel/80 total; UACR, 4 novel/8 total. One locus (BCAS3) was shared between CKD and eGFR, and another (WIPF3) between eGFR and albuminuria, while no loci were shared between CKD and UACR. In the trans-ancestry meta-analysis with Europeans, the numbers of novel and total loci were: CKD, 1/7; eGFR, 27/547; and albuminuria, 4/24.
This study is the largest meta-GWAS of kidney-related traits in East Asians, and the combined international analysis is the largest globally. Several novel loci unique to East Asians, absent even in European analyses of more than one million individuals, indicate ancestry-specific determinants of CKD and related traits. These results provide new biological insights, highlight the importance of diverse populations in genetic research, and may guide precision medicine strategies across ancestries. Acknowledgement:This work was supported by the Japan Agency for Medical Research and Development (AMED, 25tm0424230h0002). We express our sincere gratitude to the participants and the research teams of the collaborating cohorts, whose commitment made this study possible. The following institutions contributed to the establishment of J-Kidney-Biobank: Kawasaki Medical School, the Jikei University, Kanazawa University, Kyoto University, Kyushu University, Nagoya University, Nara Medical University, Niigata University, Okayama University, Saitama Medical University, Tohoku Medical Megabank Organization, the University of Tokyo, Yokohama City University.
