Arterial Blood Gas Results as a Prognostic Factor in Acute Aluminum Phosphide Intoxication: A Prognostic Study

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Abstract Title *

Arterial Blood Gas Results as a Prognostic Factor in Acute Aluminum Phosphide Intoxication: A Prognostic Study

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Co-author 1

Muawya Alahmad muawiyah989@gmail.com Idlib University Hospital Nephrology Idlib Syrian Arab Republic *

Co-author 2

Khaleh Haj Nasan hajnaasan83@gmail.com Mohammad Wassim Maaz Hospital Nephrology Azaz Syrian Arab Republic -

Co-author 3

Wasim Zakaria wasimzakaria@Idlib.sy Idlib university internal medicine Idlib Syrian Arab Republic -

Co-author 4

Abdo Najjar drabdonajjar1974@gmail.com Ebla Hospital Critical care Idlib Syrian Arab Republic -

Co-author 5

Ahmad Musa Al-Aaraj alaraj60@gmail.com Idlib University Hospital Nephrology Idlib Syrian Arab Republic -

Co-author 6

Saleh Alyousef salehalyousef1995@gmail.com Idlib University Hospital Nephrology Idlib Syrian Arab Republic -

Co-author 7

Fouad Al Ali fouad44alali@gmail.com Idlib University Hospital Nephrology Idlib Syrian Arab Republic -

Co-author 8

Mohammad Sheikh Yousef drmohamedsheakyousef@gmail.com Idlib University Hospital Nephrology Idlib Syrian Arab Republic -

Co-author 9

Mohamed Sekkarie msekkarie@gmail.com Nephrology and Hypertension Associates Nephrology Bluefield United States -

Co-author 10

Saleh KAYSI saleh.kaysi@chu-brugmann.be Brugmann university Hospital Nephrology Brussels Belgium -

Co-author 11

Co-author 12

Co-author 13

Co-author 14

Co-author 15

Introduction

Metal phosphide poisoning is a public health issue that impacts thousands of individuals in rural regions of many low- and middle-income countries. Most cases are suicidal, mortality rates are high, and managing severe cases is challenging. Blood gas analysis is crucial for guiding treatment and predicting outcomes.

Methods

The study examines 25 patients with aluminum phosphide poisoning in northwestern Syria. Variables collected included age, gender, vital signs, mental status changes, arterial blood gases data, lactic acid levels, basic laboratory test results, treatments provided, and survival outcomes. Mortality rates were determined based on patients’ blood gas status at presentation.

Results

Four blood gas presentation patterns were identified: normal, pure metabolic acidosis, mixed metabolic acidosis with respiratory acidosis, and mixed metabolic acidosis with respiratory alkalosis. Mortality rates in these groups were 0%, 14%, 60%, and 44%, respectively.

Conclusion

Identifying the acid-base status of patients poisoned with phosphide metals can assist in management and triage. Patients showing a combination of metabolic acidosis and respiratory alkalosis need intensive care despite a nearly normal pH.

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