Clinical correlation of copeptin among diabetes mellitus patients with progressive nephropathy towards End Stage Renal Disease

Certificate Output Instructions

For best output, select "Paper Size" as "A4" and "Margin" as "0" or "None".

To save or print to PDF, please select Print Destination > Save as PDF, enable Background Graphics under "More Settings", then click "Save".

Presented the abstract " "
(Abstract co-author(s): )

Back

E-Poster Presentation

During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.

Preparing your E-Poster

Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.

E-Poster Submission Deadline

Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.

E-Poster Format Requirements

PDF file
Layout: Portrait (vertical orientation)
One page only (Dim A4: 210 x 297mm or PPT)
E-Poster can be prepared in PowerPoint (one (1) PowerPoint slide) but must be saved and submitted as PDF file.
File Size: Maximum file size is 2 Megabytes (2 MB)
No hyperlinks, animated images, animations, and slide transitions
Language: English
Include your abstract number
E-posters can include QR codes, tables and photos

E-Poster

https://storage.unitedwebnetwork.com/files/1099/80f4c2481d1a2b3ae9b2faab60ea652d.pdf

Abstract Title *

Clinical correlation of copeptin among diabetes mellitus patients with progressive nephropathy towards End Stage Renal Disease

Please follow the instructions below to input your abstract title.

Abstract titles should be brief and reflect the content of the abstract.

The title will not be accepted if it exceeds 25 words.
Type in CAPITAL LETTERS.
Lowercase may be used for abbreviations only, for example, mRNA.

Co-author 1

MUHAMMAD TASSADUQ KHAN khan_smc@yahoo.com Dow university hospital Renal transplant unit karachi Pakistan *

Co-author 2

tooba noor tooba.noor@duhs.edu.pk dow university hospital renal transplant unit karachi Pakistan -

Co-author 3

farina hanif farina.hanif@duhs.edu.pk dow university hospital renal transplant unit karachi Pakistan -

Co-author 4

Co-author 5

Co-author 6

Co-author 7

Co-author 8

Co-author 9

Co-author 10

Co-author 11

Co-author 12

Co-author 13

Co-author 14

Co-author 15

Introduction

Background: Diabetic nephropathy is the leading cause of End Stage Renal Disease. Arginine Vasopressin (AVP) plays pivotal role in osmoregulation and renal water conservation. As diabetic patients are prone to develop renal complications, AVP system is considered as a novel target to be evaluated for possible disruption. Copeptin, a surrogate biomarker of AVP, is preferred over AVP due to comparatively stable structure and prolonged half-life.

The study is designed to correlate the levels of copeptin among diabetes mellitus patients with worsening renal outcomes.

Methods

Methods: It was a comparative cross-sectional study. Individuals were stratified into progressive deteriorating stages of nephropathy as per NKF KDOQI guidelines. Different biochemical variables HbA1c, serum BUN, serum creatinine UACR and GFR were got done from the affiliated lab. Serum copeptin levels were determined using Copeptin sandwich ELISA technique. Data was analyzed through Statistical Program for Social Sciences (SPSS).

Results

Out of the 120 subjects, 30% of them (n = 36) developed severely decreased kidney function with GFR less than 30mL/min/1.73m2. Copeptin levels were seen to be progressively increased with stages of albuminuria (385.297±288.36 pg/ml at stage 3) with positive correlation i.e. r = 0.375, p = ≤0.001 and negatively correlated with decline in GFR (291.73±268.82 pg/ml at stage 5) i.e. r = -0.409, p = ≤0.001.

Conclusion

Significant association of copeptin with worsening of renal functions in DM implies the pivotal role of AVP system in osmoregulation and body homeostasis. Timely detection may eventually delay the progression of ESRD and its consequences.

Kewords