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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Systemic lupus erythematosus (SLE) is characterized by the deposition of immunoglobulin (Ig)G in tissues, which in turn activates the classical pathway of complements such as C1q, C4, and C3, thus mobilizing inflammatory cells and causing tissue damage. The organs affected by SLE include the kidneys, where deposition of IgG, C1q, and C3 is seen, allowing disease activity to be assessed as lupus nephritis in renal tissue and making kidney biopsy an essential test in SLE. However, once patients have developed end-stage renal failure and require hemodialysis, kidney biopsy is no longer an effective method for assessing SLE activity. We report a case in which a skin biopsy confirmed a relapse of systemic lupus erythematosus (SLE) in a patient with end-stage renal disease undergoing hemodialysis.
A 75-year-old woman with systemic lupus erythematosus (SLE) diagnosed at age 42 initiated hemodialysis at age 75, and subsequently discontinued immunosuppression. Within 3 months of starting hemodialysis, she developed hypocomplementemia with CH50 of 20 U/ml (reference range, 31-58 U/ml), and a rise in anti-double-stranded DNA antibodies 28.3 U/ml (reference value, < 10.0 U/ml). Subsequently, generalized pruritic erythema appeared, requiring hospitalization. As the patient was already receiving hemodialysis, we proceeded with a skin biopsy of the rash.
Skin biopsy showed inflammatory infiltrates with marked erythrocyte extravasation in the dermis. Direct immunofluorescence study showed a continuous band-like deposition of immunoglobulin (Ig)G, C3, and C1q deposition at the epidermal-dermal junction “lupus band test”. Electron microscopy confirmed electron-dense deposits (EDD) at the same location. These findings indicated cutaneous manifestation of SLE and supported a diagnosis of SLE relapse.
When kidney biopsy is not feasible due to dialysis, skin biopsy serves as a valuable diagnostic tool to identify SLE relapse.
