ASSOCIATION BETWEEN SERUM FETUIN-A LEVEL AND ABDOMINAL AORTIC CALCIFICATION IN PEOPLE LIVING WITH MAINTENANCE HAEMODIALYSIS

 

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ASSOCIATION BETWEEN SERUM FETUIN-A LEVEL AND ABDOMINAL AORTIC CALCIFICATION IN PEOPLE LIVING WITH MAINTENANCE HAEMODIALYSIS

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Aung Kyaw
Myint
Aung Kyaw Myint akmpathology25@gmail.com Defence Services Medical Academy Pathology Yangon Myanmar *
Khin Phyu Pyar khinphyupyar@gmail.com Defence Services Medical Academy Medicine Yangon Myanmar -
Moe Zaw Myint drmoezawmyint@gmail.com No.1 Defence Services General hospital Medicine Yangon Myanmar -
Win Kyaw Shwe dr.winkyawshwe@gmail.com No.1 Defence Services General Hospital Nephrology Yangon Myanmar -
Zar Ni Htet Aung znha474@gmail.com No.1 Defence Services General Hospital Medicine Yangon Myanmar -
Chan Nyein Latt channyeinlatt@gmail.com No.1 Defence Services General Hospital Medicine Yangon Myanmar -
Myo Min Thant myomint07@gmail.com No.1 Defence Services General Hospital Nephrology Yangon Myanmar -
Lay Mg Mg laymgmg082@gmail.com Defence Services Medical Academy Nephrology Yangon Myanmar -
Nyan Lin Maung dr.nyanlinmg@gmail.com Defence Services Medical Academy Medicine Yangon Myanmar -
Sein Kyaw drskimaging@gmail.com No.1 Defence Services General Hospital Radiology Yangon Myanmar -
Ohnmar Hlaing ohnmarradiologist@gmail.com Defence Services Medical Academy Radiology Yangon Myanmar -
Thidar Sein dr.thidarsein@gmail.com No.1 Defence Services General Hospital Radiology Yangon Myanmar -
Tin Moe Mya tinmoemya@gmail.com No.1 Defence Services General Hospital Pathology Yangon Myanmar -
San San Win drsswinpatho@gmail.com Defence Services Medical Academy Pathology Yangon Myanmar -
Soe Soe Myint dr.soesoemyint65@gmail.com No.1 Defence Services General Hospital Radiology Yangon Myanmar -

People living with maintenance haemodialysis have high mortality due to cardiovascular events which are related with vascular calcification. Serum Fetuin-A level was related with abdominal aortic calcification. 

After getting informed consent, blood was taken for serum fetuin-A level estimation. Serum fetuin-A level was measured by the quantitative sandwich enzyme immunoassay technique. The reference range is 303-671(μg/mL) (R&D Systems, Inc.) (U.S.A). Lateral lumber spine Xray was taken and abdominal aortic calcification score (AAC) was calculated; severity is determined with Kaupilla score (0-24). Kaupilla score ‘1 and above’ is taken as calcification present.

A total of 96 people living with maintenance haemodialysis were enrolled. The mean AAC score was 3.64 ± 4.86 and 61.5% (60/96) of paticipants had positive AAC score. A quarter 24.7% (24/96) had significant AAC score (score ³ 5); and 37.5% (36/96) had AAC score ‘Zero’. Mean age was 51 years. Mean Fetuin-A level was 412.3 μg/ml ± 170.5 μg/ml. And mean Fetuin-A level for those with AAC score ‘Zero’ was the highest (545.6 μg/ml ± 84.4 μg/ml) whereas it was the lowest (181.2 μg/ml ± 90.0 μg/ml) in those with significant AAC score (AAC score ³ 5). There was a statistically significant negative association between AAC score and serum fetuin-A levels (rho = - 0.854, p < 0.001).

Figure (1) Relation between serum Fetuin-A and Abdominal Aortic Calcification score (AAC score) in people living with maintenance hemodialysis (n=96)

Table (1). AAC score groups and Serum Fetuin-A level (n=96)

AAC score group

 Number of people living with maintenance hemodialysis (%)

Serum Fetuin-A level

(303-671 μg/mL)

 (Mean ± SD)

Remark

AAC score

(0-24)

96 (100)

412.3 ± 170.5

 

AAC score ‘Zero’(0)

36

(38.1%,36/96)

545.6 ± 84.4

 

AAC score

(1-24)

60

(61.9%,60/96)

 

 

AAC score

( >= 5)

24

(24.7%,24/96)

181.2 ± 90.0

AAC cut off value

5.5 by Chen et al

 > 4.5 by Bai et al

AAC score

(1-4)

36

(37.1%,36/96)

433.7 ± 96.1

 

In people living with maintenance haemodialysis, a significant negative association was found between abdominal aortic calcification and serum Fetuin-A level.

Kewords