Antibiotic prophylaxis to prevent colonoscopy- associated peritonitis in peritoneal dialysis patients

 

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Antibiotic prophylaxis to prevent colonoscopy- associated peritonitis in peritoneal dialysis patients

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Naohiro
Toda
Naohiro Toda natoda@kuhp.kyoto-u.ac.jp Kansai Electric Power Hospital Department of Nephrology Osaka Japan *
Masahiro Nakagaki masa.nakagaki@gmail.com Kokura Memorial Hospital Division of Nephrology Kitakyushu Japan -
Masashi Mizuno mizuno.masashi.z6@f.mail.nagoya-u.ac.jp Nagoya University Graduate School of Medicine Department of Renal Replacement Therapy Nagoya Japan -
Hiroyuki Kadoya hrkado121@gmail.com Kawasaki Medical School Department of General Geriatric Medicine Kurashiki Japan -
Hideaki Oka okanokao0818@yahoo.co.jp Matsuyama Red Cross Hospital Division of Kidney Center Matsuyama Japan -
Sakai Yukinao y-sakai@nms.ac.jp Graduate School of Medicine, Nippon Medical School Department of Endocrinology, Metabolism and Nephrology Tokyo Japan -
Masahiro Eriguchi meriguci@gmail.com Nara Medical University Department of Nephrology Kashihara Japan -
Takaaki Kosugi taka_kosugi25@naramed-u.ac.jp Nara Medical University Department of Nephrology Kashihara Japan -
Shouhei Yamada innocent.shohei17@gmail.com St. Marianna University School of Medicine Division of Nephrology and Hypertension, Department of Internal Medicine Kawasaki Japan -
Koji Hashimoto khashi@shinshu-u.ac.jp Shinshu University School of Medicine Department of Nephrology Matsumoto Japan -
Tomo Suzuki suzuki.tomo@kameda.jp Kameda Medical Center Department of Nephrology Kamogawa Japan -
Shunsuke Takahashi ttktto@gmail.com National Hospital Organization Kure Medical Center Department of Nephrology Kure Japan -
Takeshi Yoshida takeshi.cloud@icloud.com Tagawa Municipal Hospital Division of Nephrology Tagawa Japan -
Kiyoto Koibuchi k_koibuchi@tobu.saiseikai.or.jp Saiseikai Yokohamashi Tobu Hospital Department of Nephrology and Dialysis Yokohama Japan -
Yasuhiko Ito yasuito57@gmail.com Aichi Medical University Department of Nephrology and Rheumatology Nagakute Japan -

Peritoneal dialysis (PD)-associated peritonitis is a serious complication of PD and its prevention is important in reducing patient morbidity and mortality. Although International Society for Peritoneal Dialysis (ISPD) guideline recommends antibiotic prophylaxis prior to colonoscopy to prevent PD-associated peritonitis, optimal antibiotic regimen and route of administration have not been determined. This study aimed to investigate the actual use of antibiotic prophylaxis prior to colonoscopy in PD patients in Japan and to elucidate the optimal antibiotic prophylactic regimen and route of administration for preventing colonoscopy- associated peritonitis.

In this retrospective, multicenter observational cohort study, we investigated the incidence of colonoscopy-associated peritonitis at 14 hospitals in Japan between 2018 and 2024. Peritonitis developing within one week after colonoscopy was defined as colonoscopy-associated peritonitis. Patients with pre-existing peritonitis were excluded from the study.

A total of 626 colonoscopies were performed in 398 PD patients. Antibiotic prophylaxis was used in 360 (57.5%) procedures and PD fluid was drained before 618 colonoscopy procedures (98.7%). Of the 360 cases receiving prophylactic antibiotics, 179 received them intravenously and 181 orally. Prophylactic antimicrobial regimens were used in various forms; 64% were single-agent therapies, while the rest were combinations of multiple agents. There were five episodes of peritonitis within 1 week after colonoscopy (0.8%). Two of the five episodes had received intravenous cephalosporins prophylactically, and three of the five episodes occurred without antibiotic prophylaxis. There were no episodes of peritonitis following oral antibiotic prophylaxis. Although there was no statistically significant difference, the incidence rate of peritonitis was 1.13% without antibiotics and 0.56% with antibiotics, both of which were lower than the previously reported rates of 4–12% with prophylaxis and 0–12% without prophylaxis. The causative pathogens of peritonitis were Escherichia coli in two cases, MRSA in one case, and two culture-negative cases. All episodes of colonoscopy-associated peritonitis showed clinical improvement with antibiotic treatment.

The incidence of colonoscopy-associated peritonitis in Japan was low; notably, oral antibiotic prophylaxis appeared to be effective.

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