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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Low-protein diets (LPDs) are recommended for patients with advanced chronic kidney disease (CKD). However, the efficacy and safety of LPDs in patients with CKD are not clear. Moreover, in most clinical trials, patients have difficulty adhering to dietary protein restriction. Rice, a major staple food worldwide, is the most consumed plant protein source in Asia. In the RICE study, which lasted for 24 weeks, we demonstrated the feasibility of low-protein rice (LPR) as a tool for efficiently reducing dietary protein intake in patients with CKD (Hosojima M, et al. Kidney360, 2022). However, long-term studies are needed to investigate the effectiveness of an LPR-based diet to suppress CKD progression. Therefore, we conducted a long-term prospective study involving the use of LPR (the RICE2 study).
A multicenter, randomized controlled trial was conducted from September 2019 to March 2024 that involved 112 CKD patients (mean age: 63.1±10.8 years) with stage G3aA2 to G4 receiving outpatient care at Niigata University and seven affiliated hospitals. Participants were randomly assigned to either a control group receiving only nutritional guidance (no LPR group) to achieve the nutritional goal (dietary protein restriction [0.7 g/kg ideal body weight/day]) or to an intervention group receiving nutritional guidance and LPR (at least twice daily; LPR group) for 120 weeks. Creatinine clearance (Ccr, ml/min) and urinary protein were calculated from accurately collected 24-h urine samples. Dietary protein intake was estimated using Maroni’s formula, while energy intake was estimated based on a dietary survey conducted by registered dietitians. This study aimed to compare the impact on renal function over time and assess its usefulness in adherence to an LPD (trial registration number: jRCTs031190063).
There was no significant difference between the groups in renal function change, as measured by Ccr, from baseline to 120 weeks (LPR group: −8.811 [95% CI: −11.649, −5.973]; no LPR group: −6.284 [−9.218, −3.351]). Renal prognosis also showed no significant differences between the two groups, as defined by events such as the initiation of renal replacement therapy or a 50% reduction in Ccr. There was no significant difference in the change in urinary protein between the two groups. Throughout the study period, the LPR group had significantly lower protein intake and higher energy intake. The two groups showed no significant difference in skeletal muscle mass change, as assessed by segmental multiple-frequency bioelectric impedance measurements. No specific complications were associated with the use of LPR during the intervention period.
The RICE2 study did not find a significant effect of an LPR-based LPD on slowing the decline in renal function in patients with CKD. Further research is needed to clarify the impact of LPDs on the progression of renal dysfunction. Nonetheless, LPR appears to be a useful tool for facilitating adherence to LPDs.
