Impact of Body Mass Index on Renal and Cardiovascular Outcomes in Japanese Autosomal Dominant Polycystic Kidney Disease

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https://storage.unitedwebnetwork.com/files/1099/afb16215369b73357c30e7c39a016a44.pdf

Abstract Title *

Impact of Body Mass Index on Renal and Cardiovascular Outcomes in Japanese Autosomal Dominant Polycystic Kidney Disease

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Co-author 1

Jun Muratsu muratasu@cgt.med.osaka-u.ac.jp Rinku General Medical Center Nephrology Izumisano City Japan *

Co-author 2

Yan Zhang skybluedream@ymail.ne.jp Rinku General Medical Center Health Care Center Izumisano City Japan -

Co-author 3

Eriko Umakoshi cellandgo0521@ymail.ne.jp Rinku General Medical Center Nephrology Izumisano City Japan -

Co-author 4

Yuya Kamada aries01@ymail.ne.jp Rinku General Medical Center Radiology Izumisano City Japan -

Co-author 5

Makiko Morita aurora.curtain@ymail.ne.jp Rinku General Medical Center Nephrology Izumisano City Japan -

Co-author 6

Masato Hayashi stargatesky@ymail.ne.jp Rinku General Medical Center Nephrology Izumisano City Japan -

Co-author 7

Ayaka Nariyama constellations@ymail.ne.jp Rinku General Medical Center Nephrology Izumisano City Japan -

Co-author 8

Kota Okamoto polaris0101@ymail.ne.jp Rinku General Medical Center Nephrology Izumisano City Japan -

Co-author 9

Tatsuya Wada shou3ki3ki@yahoo.co.jp Rinku General Medical Center Nephrology Izumisano City Japan -

Co-author 10

Shigeaki Nishiike komekomesugusugu@yahoo.co.jp Rinku General Medical Center Radiology Izumisano City Japan -

Co-author 11

Daisaku Masuda d.masudaa@ymail.ne.jp Rinku General Medical Center Cardiology Izumisano City Japan -

Co-author 12

Shizuya Yamashita minamisouth0214@yahoo.co.jp Rinku General Medical Center Cardiology Izumisano City Japan -

Co-author 13

Takashi Shigematsu docteur_shigemat@iris.eonet.ne.jp Rinku General Medical Center Nephrology Izumisano City Japan -

Co-author 14

Co-author 15

Introduction

Although obesity has been associated with kidney volume expansion and faster progression in autosomal dominant polycystic kidney disease (ADPKD), the relationship between body mass index (BMI) and cardiovascular disease (CVD) in this population remains unclear. This study aimed to investigate the association between BMI and CVD in patients with ADPKD using both institutional clinical data and a national dialysis registry.

Methods

This study consisted of two parts. First, a single-center retrospective observational study was conducted in 44 ADPKD patients regularly followed by nephrologists at Rinku General Medical Center between 2010 and 2023. Multivariable logistic regression was used to assess the association between BMI and CVD prevalence. Second, we analyzed data from 3,318 ADPKD patients who newly initiated renal replacement therapy (RRT) between 2019 and 2023 using the Japanese Society for Dialysis Therapy (JSDT) Renal Data Registry. Univariable logistic regression analysis was performed to evaluate the association between BMI and medical history of CVD prevalence.

Results

In the single-center study, multivariable analysis revealed that lower BMI was independently associated with increased CVD risk (OR: 0.34; 95% CI: 0.13–0.91; P = 0.031). In the registry study, medical history of cerebral infarction was significantly more frequent in the BMI <22 group (OR: 1.79; 95% CI: 1.34–2.39; P < 0.001).

Conclusion

Lower BMI was associated with higher CVD, especially cerebral infarction prevalence in ADPKD patients.

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