PLASMA MATRIX METALLOPROTEINASE-2 AND LOWER DEPRESSIVE SYMPTOMS IN PATIENTS UNDERGOING HEMODIALYSIS

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PLASMA MATRIX METALLOPROTEINASE-2 AND LOWER DEPRESSIVE SYMPTOMS IN PATIENTS UNDERGOING HEMODIALYSIS

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Co-author 1

Jae-Hong Ryoo armani131@hanmail.net Kyung Hee University, School of Medicine Department of Occupational and Environmental Medicine Seoul Korea (Republic of) -

Co-author 2

Dong-Young Lee biizz@hanmail.net Veterans Health Service Medical Center Department of Internal Medicine Seoul Korea (Republic of) *

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Introduction

Matrix metalloproteinases-2 and matrix metalloproteinases-9 have major roles in the degradation of the extracellular matrix, a primary component of tissue structure and are concerned with inflammation. Patients undergoing hemodialysis are prevalent of depression. Inflammation is one of the leading causes of depression. This study explored the connection between plasma matrix metalloproteinases-2/matrix metalloproteinases-9 and depression in patients undergoing hemodialysis.

Methods

We evaluated 172 patients undergoing hemodialysis to find out the relationship between matrix metalloproteinases-2 and matrix metalloproteinases-9 and depressive symptoms using the Beck Depression Inventory questionnaire. Linear regression was used to examine the association between levels of matrix metalloproteinases-2 and matrix metalloproteinases-9 and Beck Depression Inventory scores. A Cox proportional hazards model was used to evaluate the risk of developing depressive symptoms.

Results

Linear regression analysis revealed a significant inverse association between matrix metalloproteinases-2 levels and Beck Depression Inventory scores (adjusted β: -2.469, (95% CI: -4.267 - -0.671)). Cox proportional hazards regression analysis showed that participants in the highest tertile of matrix metalloproteinases-2 had a significantly lower risk of developing depressive symptoms over two years (Hazard Ratio: 0.280, (95% CI: 0.080 - 0.977)).

Conclusion

Our study concluded that there is a significant inverse association between plasma levels of matrix metalloproteinases-2 and baseline Beck Depression Inventory scores. Those with highest tertile of matrix metalloproteinases-2 showed significantly lower incidence of depressive symptoms over 2 years.

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