A SYSTEMATIC REVIEW AND META-ANALYSIS OF INITIATIVES TO ENHANCE REFERRAL PATTERNS FROM PRIMARY CARE TO SPECIALIST KIDNEY CARE

 

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https://storage.unitedwebnetwork.com/files/1099/2569a68f89368b8ba7d15e09745f5b20.pdf
A SYSTEMATIC REVIEW AND META-ANALYSIS OF INITIATIVES TO ENHANCE REFERRAL PATTERNS FROM PRIMARY CARE TO SPECIALIST KIDNEY CARE

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Anukul
Ghimire
Anukul Ghimire anukul@ualberta.ca University of Toronto Medicine Toronto Canada *
Vinash Hariramani vinashkumar@yahoo.com University of Alberta Medicine Edmonton Canada -
Abdullah Abdulrahman jiindhe4@gmail.com University of Alberta Medicine Edmonton Canada -
Feng Ye fye@ualberta.ca University of Alberta Medicine Edmonton Canada -
Janice Kung janice.kung@ualberta.ca University of Alberta Medicine Edmonton Canada -
Somkanya Tungsanga tungsang@ualberta.ca University of Alberta Medicine Edmonton Canada -
Soroush Shojai shojai@ualberta.ca University of Alberta Medicine Edmonton Canada -
Ikechi Okpechi iokpechi@ualberta.ca University of Alberta Medicine Edmonton Canada -
Aminu Bello aminu1@ualberta.ca University of Alberta Medicine Edmonton Canada -
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The rising prevalence in chronic kidney disease (CKD) has led an increase in referrals to kidney specialists. This has inadvertently resulted in a large volume of referral of patients who do not require specialist kidney care and has further strained the global nephrology workforce. There remains limited data on interventions to enhance referral patterns from primary care to nephrology. We conducted a systematic review of studies assessing interventions for reducing wait times, decreasing the volume of referrals, and/or increasing proportion of guideline concordant referrals from primary care to specialized kidney care services across all world regions. 

We leveraged MEDLINE, Embase, Cochrane Library, CINAHL, Web of Science and PsycINFO for studies (from inception to April 15, 2024) reporting interventions aimed at decreasing referral volume, reducing wait-times, and/or increasing guideline-concordant referrals in adult patients with CKD from primary care to nephrology. Interventions were further classified into taxonomy of initiatives, specific type of intervention, and whether they were single vs. multi-faceted interventions. Primary outcomes included changes to referral volume, wait-times, and proportion of guideline-concordant referrals. Data was pooled using a random effects model and meta-analyses were conducted using pooled mean-difference (MD) and odds-ratios (OR).

Our search yielded 33 studies, with 20 studies reporting single interventions and 13 using more than one intervention. None of the studies took place in low- or middle-income countries (LMIC). Overall, interventions resulted in an increase in total referrals (MD: 19 referrals per month, 95% CI, 7 to 30; I2=98%; P<0.001) and a non-significant decrease in the proportion of guideline-concordant referrals (OR: 0.32, 95% CI, 0.09 to1.16; I2=100%; P=0.08). Financial, regulatory, or legislative incentives (n=2) led to an increase in guideline-concordant referrals (OR: 1.15, 95% CI, 1.02 to1.29; I2: 0%; P=0.02). Organizational changes showed a non-significant reduction in wait-time of 24 days (95% CI -64 to 15, I2 = 99%; P =0.23) but tended to decrease guideline concordant referrals (OR: 0.17, 95% CI, 0.03 to 0.86; I2: 100%; P=0.03). 

Table 1. Characteristics of the studies included in the review pp

Overall, interventions largely increased referral volume and decreased guideline-concordant referrals. Organizational changes tended to decrease wait-times. Our work signals the need for further work in designing and implementing strategies to enhance referral patterns to nephrology, particularly from LMIC. The data has implications for designing programs to improve primary care-nephrology interface in kidney disease management. Select content from this abstract has previously been presented at the 2023 ASN Kidney Week Meeting.

Kewords