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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Glomerular enlargement with increased glomerular diameter can precede various renal diseases such as diabetic nephropathy, Focal Segmental Glomerular Sclerosis (FSGS), obesity related glomerulopathy (ORG) and Transplant nephropathy. With the advent of Whole Slide digital Imaging (WSI), accurate measurement of glomerular diameter is possible. The diameter could add valuable information in understanding and prognostication of a disease. This study aims to compare the glomerular diameter in diabetes with that in normal subjects and to correlate the increase in diameter with levels of 24hr proteinuria and eGFR. This study aims to compare the glomerular diameter in diabetes with that in normal subjects and furthermore, to correlate the increase in diameter with levels of 24hr proteinuria and eGFR.
This study was conducted in the Department of Histopathology, Apollo Hospitals, Jubilee Hills, Hyderabad with 50 adult renal biopsies with a minimum of 8 viable glomeruli with a diagnosis of diabetic nephropathy and no associated non-diabetic renal disease. Slides were scanned using the Philips Intellisite Ultrafast scanner UFS300. One good section was selected and 2 perpendicular diameters for every viable glomerulus in the section was taken and the mean calculated for each case and the cohort. The normal cohort comprised of glomeruli from nephrectomy of 30 non-obese adults, non-diabetic, non-hypertensive with no proteinuria and normal e GFR. Proteinuria was stratified into ≤3.5 gm/day and >3.5gm/day.
A mean difference of 26.3 micrometers between normal glomeruli and glomeruli in diabetic nephropathy. The increase in size has been shown to correlate with the decrease in eGFR and increasing proteinuria in this study, implying that increased matrix affects function in diabetic nephropathy. In a ROC analysis, using a cut off value of 191 micrometers, a sensitivity of around 57% and specificity of 65 to 70% was obtained for prediction of eGFR<60 mL/min and proteinuria of >3.5gm/day.
Glomerular diameter in diabetic nephropathy is significantly higher than in normal group and the increase is correlated with decreasing eGFR and increase in proteinuria. As the diameter can be accurately measured with no inter-observer variation, this index can add value to routine biopsy reports. By analysing a large number of cases, it may be possible to arrive at a figure of glomerular diameter which will be predictive of significant proteinuria and decreased eGFR. Very few such studies are available and they have employed complicated techniques and mathematical equations for obtaining the size.
