Necroscopic findings in snakebite envenoming due to Bothrops: case report

 

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Necroscopic findings in snakebite envenoming due to Bothrops: case report

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Elizabeth
Daher
Davi Acselrad daviacselrad@edu.unifor.br University of Fortaleza Medicine Fortaleza Brazil -
Gustavo Pinto gustavoneves@edu.unifor.br University of Fortaleza Medicine Fortaleza Brazil -
Eloiza Miranda eloizamiranda@gmail.com University of Fortaleza Medicine Fortaleza Brazil -
Yuri Fraga yurifraga@gmail.com University of Fortaleza Medicine Fortaleza Brazil -
Gabriel Parente parentegabriel@edu.unifor.br University of Fortaleza Medicine Fortaleza Brazil -
Marcelo Filho marceloleitefer@gmail.com University of Fortaleza Medicine Fortaleza Brazil -
Erick Mota erickfeitosa03@edu.unifor.br University of Fortaleza Medicine Fortaleza Brazil -
Alex Albuquerque alexkarrel@yahoo.com.br Charles Darwin University Medicine Darwin Australia -
Renata Nunes renatanunes@gmail.com Perícia Forense of Ceara Medicine Fortaleza Brazil -
Tiago Maia Tiagocmaiaa@gmail.com University of Fortaleza Medicine Fortaleza Brazil -
Isis Holanda isisbatistaholanda@edu.unifor.br University of Fortaleza Medicine Fortaleza Brazil -
Elizabeth Daher ef.daher@uol.com.br Federal University of Ceara Medicine Fortaleza Brazil *
Polianna Albuquerque polianna.albuquerque@cdu.edu.au Charles Darwin University Medicine Darwin Australia -
Priscila Ye Wenyan Yewenyan1@hotmail.com University of Fortaleza Medicine Fortaleza Brazil -
Geraldo Junior geraldobsilvajr@yahoo.com University of Fortaleza Medicine Fortaleza Brazil -

Snakebite envenoming is a global public health issue, reclassified by WHO as a neglected tropical disease. In Brazil, Bothrops species cause 80–90% of cases, with high morbidity and mortality). Fatalities are often associated with systemic bleeding, shock, respiratory failure, and acute kidney injury (AKI), the main cause of death in snakebite victims.

Case report: A 65-year-old rural worker was bitten on the fifth right toe, presenting pain, edema, paresthesia, and clotting time >30 min. Admission laboratory values are summarized in Table 1. Initially classified as mild, he received three vials of antibothropic serum. Four hours later, he developed hypotension, blurred vision, abdominal pain, anemia, and thrombocytopenia (Table 1[GB1] ). Reclassified as severe, he received nine more vials, but died ten hours post-bite. Necropsy revealed edema and punctiform lesions on the right foot, moderate hemothorax, intense pulmonary congestion, softened liver, and cerebral edema with intraparenchymal hemorrhages. Although no macroscopic renal alterations were noted, the clinical course suggested high risk of AKI due to shock, coagulopathy, and hemolysis, mechanisms well established in Bothrops accidents.

Parameters

8h

(admission)

12h

Reference values

Hemoglobin (g/dL)

13.9

7.4g

12-17

Hematocrit (%)

43.8

23.3

36-50

Platelets (/dL)

187.000

133.000

150-400 x 10³

Leukocytes (/dL)

10.500

13.000

5-11 x 10³

Segmented (%)

71

73

45-70

Band cells (%)

2

2

0

Clotting time (min)

>30

*

5-10

Creatinine (mg/dL)

1

*

<1.5

Urea (mg/dL)

42

*

10-50

Table 1

 

Bothropic venom exerts proteolytic, coagulant, and hemolytic effects, leading to edema, coagulopathy, and systemic bleeding. Complications such as hemorrhage, shock, sepsis, respiratory failure, and especially AKI are strongly associated with mortality. Older victims usually show worse prognosis due to reduced renal reserve and comorbidities. In this case, deterioration occurred despite reclassification and serum therapy in accordance with guidelines. Necroscopic findings aligned with previously described Viperidae cases.

Fatal Bothrops cases often involve systemic bleeding, shock, and AKI. This case emphasizes the need for vigilant monitoring, early reclassification, and recognition of renal risk even before laboratory evidence of AKI. Necroscopic findings reinforce the systemic effects of the venom and support improvements in snakebite care and prevention strategies

Kewords