OMNIPRESENT SUPERBUGS AND LACK OF ANTI-MICROBIAL RESISTANCE AWARENESS – A DOUBLE WHAMMY IN CKD

 

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OMNIPRESENT SUPERBUGS AND LACK OF ANTI-MICROBIAL RESISTANCE AWARENESS – A DOUBLE WHAMMY IN CKD

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KRUPA
KRISHNAN
KRUPA KRISHNAN krupakrishnan0412@gmail.com Bombay Hospital Institute of Medical Sciences Nephrology Mumbai India *
KRIYA SHAH kriya3102@gmail.com University of Nottingham Medical School Medical School Nottingham United Kingdom -
HARDIK SHAH drhardik74@gmail.com Bombay Hospital Institute of Medical Sciences Nephrology Mumbai India -
ASMITA SAKLE microbhmumbai@yahoo.com Bombay Hospital Institute of Medical Sciences Microbiology Mumbai India -
DILIP KIRPALANI dilip_kirpalani@yahoo.com Bombay Hospital Institute of Medical Sciences Nephrology Mumbai India -
SATARUPA DEB dr.satarupadeb@gmail.com Bombay Hospital Institute of Medical Sciences Nephrology Mumbai India -
SHRIRANG BICHU shrirangbichu@gmail.com Bombay Hospital Institute of Medical Sciences Nephrology Mumbai India -
ASHOK KIRPALANI ashoklkirpalani@gmail.com Bombay Hospital Institute of Medical Sciences Nephrology Mumbai India -
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Traditionally, nosocomial urinary tract infections (UTI’s) have higher preponderance for antimicrobial resistance (AMR). However, the recent spurt in AMR amongst community acquired UTI`s additionally is alarming. Lack of data regarding epidemiology and AMR pattern, emergence of newer pathogens with de novo AMR as well as a poor knowledge, attitude, belief and behaviour (KABB) towards antimicrobial usage in the general population has possibly led to the catastrophic health challenges in our country. In this study, the spectrum of microbes and antimicrobial resistance pattern of patients(pts.) with UTI in a critical care setup shall be compared with those having UTI’s in the community and outpatient setup. 

A retrospective analysis of demographic data and urine cultures with antimicrobial sensitivity pattern of pts. presenting with UTI either in the ICU (Group A) or in outpatient (Group B) setting between January 2023 to December 2024 was done. A 15-point questionnaire based KABB survey regarding awareness about antimicrobial usage and AMR was given to patients, caregivers and visitors.

The first positive culture from 594 pts. of Group A and 2174 pts. of Group B had bacterial isolates as follows: Group A: E.coli- 44%, Klebsiella-34%, Pseudomonas-15%, Proteus-3%, Enterococcus-1%, Miscellaneous-3% and Group B: E.coli- 58%, Klebsiella-25%, Pseudomonas-8%, Proteus-4%, Enterococcus-4%, Miscellaneous-1%.

                        Table 1: Comparison of AMR pattern for Gram Negative Bacteria

Antibiotic

E.coli

Klebsiella

Pseudomonas

Proteus

 

Grp A

Grp B

Grp A

Grp B

Grp

 A

Grp

B

Grp

A

Grp B

Meropenem

44

33*

66

60*

58

32

6

2

Imipenem

45

34*

65

62*

59

31

5

3

Piperacillin+Tazobactam

62

51*

75

67*

61

40

6

3

3rd Gen. Cephalosporins

85

67*

84

76*

58

41

47

47*

Cefoperazone+Sulbactam

48

37*

70

67*

56

39

3

10

Amikacin

23

10

44

41*

58

46

19

20

Levofloxacin

80

78*

79

71*

68

64*

82

84*

For Gram Positive bacteria (predominant- enterococcus), resistance for Vancomycin was 26% and 18*%; whereas for Teicoplanin, it was 26% and 16*% in Groups A and B respectively.{*P value statistically significant (Pearson chi-square test)}.

1152 subjects surveyed. Only 45% were aware of what an “antibiotic” is; as many as 56% took antibiotics without prescription, 38% used leftover medications, 62% stopped the antibiotic course midway and 74% were unaware about the terms – antimicrobial or antibiotic resistance. 

Similarity of spectrum of microbes causing UTI between critically ill hospitalized patients and outpatients, as well as lack of difference in the AMR pattern between these two groups is alarming and could be just the tip of the iceberg. Lack of awareness about AMR and unregulated antibiotic consumption in the general population will add fuel to the fire to this burning health issue. 

Kewords