Acupuncture-Assisted Recovery Following Severe Urosepsis with Perinephric Abscess Rupture: A Time-Series Evaluation during ICU and Ward Phases

Certificate Output Instructions

For best output, select "Paper Size" as "A4" and "Margin" as "0" or "None".

To save or print to PDF, please select Print Destination > Save as PDF, enable Background Graphics under "More Settings", then click "Save".

Presented the abstract " "
(Abstract co-author(s): )

Back

E-Poster Presentation

During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.

Preparing your E-Poster

Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.

E-Poster Submission Deadline

Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.

E-Poster Format Requirements

PDF file
Layout: Portrait (vertical orientation)
One page only (Dim A4: 210 x 297mm or PPT)
E-Poster can be prepared in PowerPoint (one (1) PowerPoint slide) but must be saved and submitted as PDF file.
File Size: Maximum file size is 2 Megabytes (2 MB)
No hyperlinks, animated images, animations, and slide transitions
Language: English
Include your abstract number
E-posters can include QR codes, tables and photos

E-Poster

https://storage.unitedwebnetwork.com/files/1099/9049de975578ea21186cc5519d904d88.pdf

Abstract Title *

Acupuncture-Assisted Recovery Following Severe Urosepsis with Perinephric Abscess Rupture: A Time-Series Evaluation during ICU and Ward Phases

Please follow the instructions below to input your abstract title.

Abstract titles should be brief and reflect the content of the abstract.

The title will not be accepted if it exceeds 25 words.
Type in CAPITAL LETTERS.
Lowercase may be used for abbreviations only, for example, mRNA.

Co-author 1

Yichin J. Lu ycl0426@cgmh.org.tw Chang Gung Memorial Hospital Department of Traditional Chinese Medicine Taoyuan Taiwan * Chang Gung University Graduate Institute of Traditional Chinese Medicine, School of Chinese Medicine, College of Medicine Taoyuan Taiwan

Co-author 2

Hsuan Miao Liu hsuanmliu@mail.cgu.edu.tw Chang Gung University Graduate Institute of Traditional Chinese Medicine, School of Chinese Medicine, College of Medicine Taoyuan Taiwan -

Co-author 3

TzungYan Lee joyamen@mail.cgu.edu.tw Chang Gung University Graduate Institute of Traditional Chinese Medicine, School of Chinese Medicine, College of Medicine Taoyuan Taiwan - Chang Gung Memorial Hospital Department of Traditional Chinese Medicine Keelung Taiwan

Co-author 4

YuSheng Chen cusp01@cgmh.org.tw Chang Gung Memorial Hospital Department of Traditional Chinese Medicine Taoyuan Taiwan - Chang Gung University School of Traditional Chinese Medicine Taoyuan Taiwan

Co-author 5

Co-author 6

Co-author 7

Co-author 8

Co-author 9

Co-author 10

Co-author 11

Co-author 12

Co-author 13

Co-author 14

Co-author 15

Introduction

Perinephric abscess rupture complicated by urosepsis poses significant risk of delayed renal recovery and increased morbidity. Acupuncture has been reported to modulate the autonomic nervous system and attenuate inflammatory responses, yet its application in acute septic renal injury remains untested. This study aimed to determine whether adjunctive acupuncture sessions facilitate renal functional recovery and systemic stability in a patient with severe urosepsis.

Methods

We conducted a single-case time-series intervention in a 62-year-old F admitted with urosepsis and perinephric abscess rupture; initial management included percutaneous drainage (day 1) and surgical debridement (day 3). From day 5 to day 40 the patient received 13 acupuncture sessions targeting bilateral ST36, SP9 and LI11 points of traditional Chinese medicine, while standard critical care persisted. Daily measurements included estimated glomerular filtration rate (eGFR), C-reactive protein (CRP), white blood cell count (WBC), heart rate and body temperature. Interrupted time-series (ITS) modelling and 1,000-iteration random-day permutation tests assessed changes in eGFR slope, inflammatory markers and hemodynamic variables pre- and post-acupuncture.

Results

Across the ICU-to-ward transition, eGFR increased while CRP/WBC declined; HR and temperature progressively normalized. The eGFR cumulative effect showed a near-significant upward trend (β = +0.42, p_perm = 0.06) and was toward the upper tail of the permutation null; no acupuncture-related adverse events were recorded. The patient achieved clinical stability and was transferred from ICU to the ward within 14 days. Figure 2A. Trends of eGFR, CRP, and WBC in relation to acupuncture treatment days ICU (June 16–30) and ward recovery (July 1–August 19) phases are shaded. eGFR increased while CRP and WBC declined, indicating renal improvement and inflammation resolution. Figure 1. Timeline of interventions and acupuncture sessions showing drainage (June 15), debridement (June 16), ICU stay (June 16–30) , ward recovery (July 1–Aug 19) , and 13 acupuncture sessions (June 17–July 28). Observation period extended to August 19 without additional interventions. Table 2. Permutation-based ITS summary β denotes cumulative lag(0–3) effect; pₚₑᵣₘ from 1,000 random-day permutations. eGFR shows the strongest upward trend (Scenario B β = +0.42, pₚₑᵣₘ = 0.06).

Conclusion

Early ICU-phase acupuncture coincided with inflammatory resolution and renal improvement, with ICU transfer by day 14. While findings suggest a non-random recovery pattern, causality cannot be established in a single case with overlapping interventions; confirmation with multivariable models and prospective N-of-1 or pilot RCTs is warranted.

Kewords