SLEEP DEBT AND INCIDENT eGFR < 60 ml/min/1.73m² IN UNIVERSITY WORKERS WITH SHORT SLEEP DURATION: A RETROSPECTIVE COHORT STUDY

 

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https://storage.unitedwebnetwork.com/files/1099/d3a4e6a74943f99ce817c11cfcd0112e.pdf
SLEEP DEBT AND INCIDENT eGFR < 60 ml/min/1.73m² IN UNIVERSITY WORKERS WITH SHORT SLEEP DURATION: A RETROSPECTIVE COHORT STUDY

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Kanako
Oka
Kanako Oka kanako.kitamura@gmail.com the University of Osaka Department of Nephrology Osaka Japan *
Maki Shinzawa shinzawa@kid.med.osaka-u.ac.jp the University of Osaka Health and Counseling Center Osaka Japan -
Kiyoshi Masuyama masuyama@cardiology.med.osaka-u.ac.jp the University of Osaka Health and Counseling Center Osaka Japan -
Chisaki Ishibashi ishibashi.chisaki.y75@osaka-u.ac.jp the University of Osaka Health and Counseling Center Osaka Japan -
Kaori Nakanishi nakanishi.kaori.chw@osaka-u.ac.jp the University of Osaka Health and Counseling Center Osaka Japan -
Yusuke Sakaguchi sakaguchi@kid.med.osaka-u.ac.jp the University of Osaka Department of Nephrology Osaka Japan -
Isao Matsui matsui@kid.med.osaka-u.ac.jp the University of Osaka Department of Nephrology Osaka Japan -
Masayuki Mizui mmizui@kid.med.osaka-u.ac.jp the University of Osaka Department of Nephrology Osaka Japan -
Yoshitaka Isaka isaka@kid.med.osaka-u.ac.jp the University of Osaka Department of Nephrology Osaka Japan -
Daisuke Kanayama kanayama.daisuke.sts@osaka-u.ac.jp the University of Osaka Health and Counseling Center Osaka Japan -
Izumi Nagatomo nagatomo.izumi.k23@osaka-u.ac.jp the University of Osaka Health and Counseling Center Osaka Japan -
Ryohei Yamamoto yamamoto.ryohei.ras@osaka-u.ac.jp the University of Osaka Health and Counseling Center Osaka Japan -
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Short sleep duration is a risk factor for various non-communicable diseases (NCDs), including chronic kidney disease. Besides short sleep duration, several studies suggested that sleep debt, defined commonly as a difference in sleep duration between weekdays and weekends, was a potential risk factor of NCDs. This study assessed a clinical impact of sleep debt on incident reduced eGFR among adults with short sleep duration.

This retrospective cohort study included 4162 employees of the University of Osaka who were 19–59 years old, reported ≤ 6 hours of sleep duration on weekdays, and had eGFR ≥ 60 ml/min/1.73 m² and negative or trace results of dipstick urinary protein at their first annual health checkup between April 2013 and March 2017. The main exposure was sleep debt index defined as the difference in self-reported sleep duration between weekdays (≤ 5 and 5–6 hour) and weekends (≤ 5, 5–6, 6–7, 7–8, 8–9 and ≥ 9 hour), which was categorized into five groups of ≤ 0, 1, 2, 3, and ≥ 4. The outcome was incident eGFR < 60 ml/min/1.73m² during the observational period until the end of March 2024. The association between the sleep debt index and incident reduced eGFR was assessed using Cox proportional hazards models adjusted for clinically relevant factors.

Among 1907 male and 2255 female employees with median age of 36 years (interquartile range 30−44), sleep debt index of ≤ 0, 1, 2, 3, and ≥ 4 was reported in 750 (18.0%), 1,549 (37.2%), 1,171 (28.1%), 449 (10.8%), and 243 (5.8%) employees, respectively. During a median observational period of 5.8 years (2.5−9.0), incident eGFR < 60 ml/min/1.73m² was observed in 301 (7.2%) employees, respectively. A multivariable-adjusted model showed that high sleep debt index was associated with incident eGFR < 60 ml/min/1.73m² (adjusted hazard ratios [95% confidence intervals]: 1.00 [reference], 1.30 [0.95, 1.78], 1.53 [1.08, 2.17], 1.66 [1.01, 2.71], and 3.76 [2.05, 6.88], respectively).

Sleep debt predicted incident eGFR < 60 ml/min/1.73m² among working adults with short sleep duration on weekdays.

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