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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Systemic inflammation is a well-documented complication in end-stage renal disease (ESRD) patients undergoing hemodialysis and is recognized as a major contributor to physical symptom burden. This inflammatory response, often triggered by the interaction between dialysis membranes and blood components, leads to elevated circulating biomarkers that may correlate with patient-reported symptom severity. Understanding these correlations may inform therapeutic strategies aimed at improving patient quality of life.
This cross-sectional study included 17 ESRD patients receiving maintenance hemodialysis at St. Paul’s Hospital, Saskatoon. Physical symptoms were assessed using a 38-item validated survey encompassing nine domains (e.g., fatigue, musculoskeletal, skin), with total scores ranging from 0 to 190. Blood samples were analyzed for inflammatory biomarkers using a multiplex Luminex ELISA platform (Bio-Plex 200 system). Biomarkers evaluated included C-reactive protein (CRP), Serpin C1, Properdin, Platelet Factor 4 (PF4), Complement C5a, IL-1β, TNF-α, IL-6, von Willebrand Factor A2, and C5b-9. Spearman’s Rank-Order Correlation was used to assess associations between biomarker levels and total and mean symptom scores.
Among participants, 44.4% exhibited high symptom burden (total score >75). The “Fatigue/Well-being” symptom category demonstrated the highest mean score, while “Blood/Clotting” had the lowest. Statistically significant correlations were identified between Serpin C1 and both total symptom score (p< 0.05) and mean symptom score (p< 0.05). TNF-α also showed a significant correlation with total symptom burden (p< 0.05). No significant associations were found for other biomarkers.
This study demonstrates a significant association between select inflammatory biomarkers—specifically Serpin C1 and TNF-α—and the severity of physical symptoms in patients undergoing hemodialysis. These findings underscore the impact of systemic inflammation on symptomatology in ESRD and suggest that modulation of inflammatory pathways, possibly through improved biocompatibility of dialysis membranes or targeted pharmacologic interventions, may offer a pathway to enhanced patient well-being.
