CLINICAL OUTCOMES OF ACUTE KIDNEY INJURY AND ITS ASSOCIATED FACTORS AMONG ELDERLY PATIENTS ADMITTED IN A PHILIPPINE TERTIARY PRIVATE HOSPITAL: A RETROSPECTIVE COHORT STUDY

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https://storage.unitedwebnetwork.com/files/1099/c536498f606063a61ebc9b3e6a58d794.pdf

Abstract Title *

CLINICAL OUTCOMES OF ACUTE KIDNEY INJURY AND ITS ASSOCIATED FACTORS AMONG ELDERLY PATIENTS ADMITTED IN A PHILIPPINE TERTIARY PRIVATE HOSPITAL: A RETROSPECTIVE COHORT STUDY

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Co-author 1

Jesus Adrian Lim jesusadrian.lim@gmail.com University of Santo Tomas Hospital Internal Medicine Section of Adult Nephrology Manila Philippines *

Co-author 2

Dexter Clifton Pe dcpe@ust.edu.ph University of Santo Tomas Hospital Internal Medicine Section of Adult Nephrology Manila Philippines -

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Introduction

Acute kidney injury (AKI) in the elderly is associated with increased morbidity and mortality, but local data remain limited. This study aimed to determine the clinical outcomes of AKI and identify associated factors among elderly patients in a Philippine tertiary hospital.

Methods

A retrospective cohort study was conducted at the University of Santo Tomas Hospital, involving 180 elderly inpatients diagnosed with AKI from 2021 to 2024. Patient profiles and outcomes were collected from medical charts. Multivariable logistic regression identified factors associated with in-hospital mortality, renal recovery, and renal replacement therapy (RRT) requirement.

Results

The median age was 75 years; 50% were male. Nearly half (49%) of the cohort presented with AKI stage 1. In-hospital mortality was 20.56% (95% CI: 14.8–27.5), renal recovery occurred in 71.11% (95% CI: 63.8–77.6), and 17.78% (95% CI: 12.4–24.5) required RRT. Heart disease was associated with increased mortality (aOR: 4.53, 95% CI: 2.07–9.94) and reduced renal recovery (aOR: 0.33, 95% CI: 0.17–0.65). RAAS inhibitor use favored renal recovery (aOR: 2.61, 95% CI: 1.05–6.52), while CKD predicted RRT need (aOR: 2.87, 95% CI: 1.17–7.06).

Conclusion

Cardiovascular comorbidity and CKD significantly impact elderly AKI outcomes. RAAS inhibitor use may support renal recovery. Integrated cardiorenal care is warranted in this population.

Kewords