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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
The relationship between kidney function and mortality in centenarians, particularly concerning hormonal regulation, remains unclear. This study aimed to investigate the association between the estimated glomerular filtration rate (eGFR) and all-cause mortality in female centenarians and explore the potential role of testosterone.
Within the China Hainan Centenarian Cohort Study (CHCCS), 701 female centenarians (median age: 102 years) were enrolled. The eGFR was calculated via the CKD-EPI 2009 creatinine equation. Restricted cubic splines (RCSs) and multivariate Cox proportional hazards models were employed to assess nonlinear associations. Subgroup analysis and likelihood ratio tests were used to evaluate the interaction effect of testosterone.
During a median follow-up of 31 months, 643 participants (91.7%) died. The RCS revealed a significant nonlinear association (P-nonlinear = 0.007; P-overall = 0.001) between the eGFR and all-cause mortality, characterized by a U-shaped curve. Multivariate-adjusted Cox regression revealed that each 10 mL/min/1.73 m² increase in the eGFR was associated with a 6.2% reduction in all-cause mortality risk (HR = 0.938, 95% CI: 0.888–0.990, P = 0.021). Compared with centenarians with eGFRs of 45-<60 mL/min/1.73 m², those with eGFRs ≤45 mL/min/1.73 m² had a 42.3% increased risk of all-cause mortality (HR = 1.423, 95% CI: 1.156–1.751, P < 0.001) and a significantly shorter median survival time (26 months vs. 34 months, P < 0.001). Higher testosterone levels attenuated the association between the eGFR and all-cause mortality, indicating a protective effect (P for multivariate nonlinear interaction = 0.018).
In female centenarians, a lower eGFR (<45 mL/min/1.73 m²) is independently associated with all-cause mortality, and this association is modified by serum testosterone levels. These findings highlight testosterone as a potential modulator of the kidney function‒mortality relationship in centenarians, although the causal relationship requires further investigation.
