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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Cranberry juice is traditionally consumed for urinary health, and its efficacy is attributed to its components such as proanthocyanidins (PACs). Although recent research has highlighted the role of urinary microbiome (urobiome) in conditions such as urinary tract infections and overactive bladders, the effects of cranberries on the urobiome of healthy individuals remain largely unknown. We have hypothesized that continuous cranberry consumption might alter the urobiome and investigated this impact in a healthy adult population.
We conducted a randomized, double-blind, placebo-controlled, crossover trial at Kansai Medical University. Forty healthy adults (21 women and 19 men) aged 20–65 years participated. Participants consumed 80 mL of cranberry juice (containing 40 mg of PACs) or a matched placebo daily for a 4-week period, followed by a 4-week washout before crossing over to the alternate intervention. Midstream urine samples were collected, and the urobiome was analyzed by sequencing the V3–V4 hypervariable regions of the 16S rRNA gene. Alpha diversity (number of observed species, Shannon index) and beta diversity (Bray–Curtis dissimilarity) were assessed. Paired comparisons were performed using the Wilcoxon signed-rank test.
At baseline, urobiome composition differed significantly between men and women (PERMANOVA, p = 0.015). The female urobiome was dominated by Lactobacillus (26.8%) and Streptococcus (18.2%), whereas the male urobiome was dominated by Streptococcus (16.7%) and Bifidobacterium (11.3%). Women also exhibited a significantly lower alpha diversity than men (p<0.05). Following the intervention period, overall alpha and beta diversity did not change significantly in men or women in either group. However, in women, cranberry juice consumption was associated with a significant reduction in the relative abundance of Lactobacillus (median 28.4% to 18.4%, p = 0.025). This effect was not observed in women who consumed the placebo, and no significant changes were detected in men.
Continuous consumption of cranberry juice induced sex-specific changes in the urobiome of healthy adults, specifically by reducing the relative abundance of Lactobacillus in women. Given that higher abundance of Lactobacillus has been reported in women with overactive bladders, this finding may provide novel mechanistic insight into the beneficial effects of cranberries on female urinary health. To our knowledge, this is the first study to report the effects of cranberry juice on the urobiome in a healthy adult population, warranting further investigation of its clinical implications.
