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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Patients with diabetic kidney disease (DKD) are more susceptible to acute kidney injury (AKI). Our RNA-seq data suggested that reactive oxygen species (ROS) may contribute to this increased sensitivity. Pyruvate dehydrogenase kinase 4 (PDK4) is a key regulator of mitochondrial metabolism. Previous studies have shown that quercetin exerts antioxidant and renoprotective effects, while IR783 is a nanomaterial responsive to oxidative stress. This study aimed to investigate the regulatory relationship between quercetin encapsulated in IR783 nanoparticles and PDK4, and their impact on AKI susceptibility in DKD.
Data from the National Health and Nutrition Examination Survey (NHANES) were used for evaluating the association between dietary quercetin intake and all-cause mortality in patients with DKD. Ischemia/reperfusion (I/R)-induced AKI models in db/m and db/db mice, and Kidney epithelial cells exposed to high glucose with or without hypoxia/reoxygenation (HG + H/R) conditions were employed. Quercetin-loaded IR783 nanoparticles were synthesized and administered in vivo and in vitro. Gain- and loss-of-function approaches targeting PDK4 and oxidative stress regulators were applied to confirm mechanistic pathways. Renal function, histopathology, oxidative stress markers, and mitochondrial activity were evaluated.
Analysis of NHANES data revealed that higher dietary quercetin intake was significantly associated with the low all-cause mortality in DKD patients. Quercetin-loaded IR783 nanoparticles significantly reduced renal tubular injury and improved renal function in I/R -db/db mice compared with free quercetin or vehicle controls. In vitro, treatment with quercetin-loaded IR783 attenuated ROS accumulation, preserved mitochondrial membrane potential. Mechanistically, nanoparticle treatment suppressed PDK4 expression and downstream oxidative stress signaling, as demonstrated that overexpression of PDK4 abolished the protective effects, whereas PDK4 knockdown mimicked the benefits of nanoparticle treatment.
Higher dietary quercetin intake is associated with reduced mortality in DKD patients, and quercetin encapsulated in IR783 nanoparticles protects against AKI in DKD by attenuating PDK4/oxidative stress signaling.
