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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Anemia in hemodialysis patients is primarily attributed to insufficient erythropoietin production. However, the capacity for erythropoietin production is not completely lost in these patients. In patients with heart failure-related anemia, erythropoietin production is often inadequate relative to the hemoglobin level, even without severe renal dysfunction, suggesting that the adjustment of erythropoietin production, rather than an inherent reduction in capacity, may be the underlying cause of insufficiency. Therefore, we hypothesized that cardiac stress induced by volume overload in hemodialysis patients might influence their endogenous erythropoietin production and anemia status.
We investigated changes in serum erythropoietin, hemoglobin, total protein, and reticulocyte levels across three consecutive hemodialysis sessions within one week in 28 patients. All patients were undergoing three times weekly hemodialysis and were not receiving erythropoiesis-stimulating agents or hypoxia-inducible factor prolyl hydroxylase inhibitors. Patients were divided into three groups based on the percentage of body weight gain at the first session of the week, relative to the weight at the end of the previous session (Group A: >5%, n=10; Group B: 3−5%, n=14; and Group C: <3%, n=4).
In Groups A and B, body weight after the first and second sessions was significantly higher than the baseline weight (the weight at the end of the previous week's last session) (Group A: 0.68±0.53 kg and 0.20±0.46 kg, respectively; Group B: 0.30±0.47 kg and 0.08±0.23 kg, respectively). In all groups, the body weight after the third session was restored to the baseline level. In Groups A and B, both total protein and hemoglobin levels at the beginning of the second and third sessions were significantly higher than those at the first session, which suggests hemoconcentration due to water removal. However, the serum erythropoietin level at the beginning of the second and third sessions increased more drastically than the total protein and hemoglobin levels in both Groups A and B (Group A: 54.1±99.2%, n.s. and 83.5±113.3%, p<0.05; Group B: 87.1±131.8%, p<0.05 and 86.7±117.8%, p<0.05, respectively). This disproportionate increase suggests a stimulation of innate erythropoietin production rather than mere hemoconcentration. Changes in serum erythropoietin, total protein, and hemoglobin levels in Group C were unremarkable, and changes in reticulocyte count were not remarkable across all groups.
This study demonstrates that endogenous erythropoietin production is stimulated by the excessive water removal necessary to correct volume overload in hemodialysis patients. Further research is needed to elucidate the underlying mechanisms of this erythropoietin stimulation and its potential influence on hematopoiesis and the patient's anemia status.
