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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Chronic kidney disease (CKD) is a global public health problem in terms of the number of patients and the cost of treatment which affects > 10% of the general population worldwide. At the 6th World Symposium on Pulmonary Hypertension (PH), the mean pulmonary arterial pressure threshold used to define PH was lowered from ≥ 25 mm of Hg to > 20 mm of Hg. Lower thresholds aim to identify patients with pulmonary hypertension two years early, as delay in diagnosis is common and has been linked to increased morbidity and a shorter lifespan.Endothelial dysfunction in patients with chronic kidney disease leads to impaired nitric oxide activity, which is not usually corrected by hemodialysis, leading to an increase in pulmonary vascular pressure. Vascular remodeling secondary to calcification and stiffening, along with a uremic toxin (e.g., ADMA), also inhibits nitric oxide and sites of Arteriovenous fistula(AVF) further exacerbating PH. Commonly associated conditions, sleep apnea episodes in CKD patients, further elevate PH risk. Adekunle et. al. stated that PH is an independent predictor of mortality in CKD patients under hemodialysis.
Study was conducted a quantitative, hospital-based descriptive cross-sectional observational study among patients admitted to the nephrology ward, diagnosed with chronic kidney disease (CKD) as per definition, and undergoing regular maintenance hemodialysis for at least three months. The study was carried out at Tribhuwan University Teaching Hospital (TUTH) Maharajgunj, a tertiary referral center where patients from different parts of the country seek treatment. A convenience sampling method was applied, and the sample size was calculated using Cochran’s formula, considering an 8% margin of error, 95% confidence interval, and prevalence of 0.51, which yielded a total of 151 participants.
The analysis of PASP status in relation to the location of arteriovenous fistula (AVF) revealed a significant association. Among patients with normal PASP, the majority (66.7%, 42 patients) had a distal fistula, whereas only 39.0% (30 patients) had a proximal fistula. In contrast, patients with pulmonary hypertension (abnormal PASP) were more likely to have a proximal fistula (61.0%, 47 patients) compared to a distal fistula (33.3%, 21 patients). This difference was statistically significant (p = 0.001), indicating that the choice of fistula site is notably associated with PASP levels, with proximal fistulas being more common among patients who develop pulmonary hypertension.
The findings demonstrate that proximal AVF sites are significantly associated with a higher prevalence of pulmonary hypertension compared to distal AVF sites. This association can be explained by the hemodynamic impact of fistula location. Proximal AVFs usually have larger blood flow volumes and create greater cardiac preload, which over time can lead to increased pulmonary artery pressure and development of pulmonary hypertension. In contrast, distal AVFs generally produce lower flow rates and impose less strain on the heart and pulmonary circulation, thereby reducing the risk of pulmonary hypertension.
