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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Approximately 9% of patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) experience cyst infections requiring hospitalization. In severe cases of cyst infection, cyst drainage is necessary. At our institution, drainage is performed for cases with persistent fever for over 1–2 weeks despite appropriate antibiotic treatment, large infected cysts exceeding 5 cm in diameter, severe infection accompanied by sepsis or disseminated intravascular coagulation, and recurrent cyst infections. While some patients experience recurrent infections necessitating repeat drainage, the risk factors for this recurrence remain unclear. This study aimed to identify the risk factors associated with the need for repeat cyst drainage.
We retrospectively analyzed 113 ADPKD patients who underwent cyst drainage for infected liver cysts between May 2018 and December 2023. This cohort was divided into two groups: the single-drainage group (n=75), who underwent drainage only once during the observation period, and the repeat-drainage group (n=38), who required re-drainage. The effect of potential factors on repeat drainage was analyzed using the log-rank test and univariate and multivariate Cox proportional hazards models. Hepatic cyst-biliary communication (HCBC) was defined as the observation of bile ducts being contrasted along with the cyst during cholangiography performed through the indwelling drainage tube.
HCBC was identified in 7 patients, all of whom belonged to the repeat-drainage group. HCBC was identified as a significant factor associated with the need for repeat drainage (Hazard Ratio [HR] 4.43, 95% Confidence Interval [CI] 1.72–11.38, P=0.002). Furthermore, hypoalbuminemia was also identified as a significant factor (HR 0.46, 95% CI 0.25–0.87, P=0.018). Although not statistically significant, there was a trend towards a higher risk for repeat drainage in patients with a history of dialysis.
Hepatic cysts originate from biliary epithelial cells and usually lose connection with the biliary system later in their development. Cysts with HCBC, such as those seen in hydatid disease or congenital biliary dilatation, are reported to have a higher risk of infection or recurrence due to persistent bile reflux and bacterial entry compared to cysts without such communication. While the common infection routes for ADPKD liver and kidney cysts are considered hematogenous or ascending, our results suggest that the presence of communication between the liver cyst and the biliary system, which is normally absent, may facilitate the spread of infection to other cysts or predispose to bloodstream infection in ADPKD. This abstract was also submitted for the 68th Annual Meeting of the Japanese Society of Nephrology.
