PHRENIC NERVE PALSY FOLLOWING CENTRAL VENOPLASTY IN A HEMODIALYSIS PATIENT: A RARE COMPLICATION

 

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https://storage.unitedwebnetwork.com/files/1099/3371f18ad5b244ab3e755d5759960b00.pdf
PHRENIC NERVE PALSY FOLLOWING CENTRAL VENOPLASTY IN A HEMODIALYSIS PATIENT: A RARE COMPLICATION

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BOON CHEOK
LAI
BOON CHEOK LAI lai.boon.cheok@singhealth.com.sg SENGKANG GENERAL HOSPITAL RENAL MEDICINE SINGAPORE Singapore *
PEI SHAN LEE lee.peishan@singhealth.com.sg SENGKANG GENERAL HOSPITAL RENAL MEDICINE SINGAPORE Singapore -
MAYANK CHAWLA mayank.chawla@singhealth.com.sg SENGKANG GENERAL HOSPITAL RENAL MEDICINE SINGAPORE Singapore -
AZMAN JOHAN azman.johan@singhealth.com.sg SENGKANG GENERAL HOSPITAL RESPIRATORY MEDICINE SINGAPORE Singapore -
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Phrenic nerve palsy is a rare but important complication following central venous interventions. Patients with end-stage kidney disease (ESKD) frequently undergo central venoplasty for vascular access dysfunction, placing them at risk of procedure-related complications. Early recognition is crucial, as diaphragmatic dysfunction may exacerbate respiratory compromise in patients with significant comorbidities.

We report a case of a 78-year-old female with ESKD on hemodialysis via a right brachiocephalic arteriovenous fistula, with known right innominate vein stenosis requiring central venoplasty using a 14 × 60 mm plain balloon (Pictures 1–2). Six weeks post-procedure, she was admitted for atrial fibrillation with rapid ventricular response and was incidentally found to have a persistently elevated right hemidiaphragm on chest X-ray (Picture 3) compared to imaging three months prior (Picture 4). Further evaluation with computed tomography (CT) of the thorax, fluoroscopy sniff test, spirometry, and respiratory muscle strength testing was performed.

Picture 1: Balloon angioplasty of the right innominate vein showing balloon shouldering at the stenotic segment.Picture 2: Post-angioplasty image demonstrating full balloon expansion indicating successful dilatation of the right innominate vein. iPicture 3: Chest X-ray at three months before central vein angioplasty

CT and chest radiography confirmed persistent right hemidiaphragm elevation without compressive lesions. The fluoroscopy sniff test demonstrated paradoxical upward motion of the right hemidiaphragm (Pictures 5–6), confirming right phrenic nerve palsy. Spirometry revealed a restrictive pattern with less than 20% reduction in forced expiratory volume in 1 second (FEV₁) from sitting (0.65 L) to supine (0.55 L). Maximal inspiratory pressure was reduced (74%) with normal expiratory pressure (98%), suggesting diaphragmatic weakness. Despite these findings, the patient remained asymptomatic with stable oxygenation. Conservative management with close monitoring was adopted, and she was discharged well with outpatient follow-up.

Picture 5: Fluoroscopy picture from Sniff Test during inspiration


This case highlights phrenic nerve palsy as an uncommon complication of central venoplasty in a hemodialysis patient. Diagnosis requires a multimodal approach, with the fluoroscopy sniff test providing definitive evidence. Recognition of this entity is essential, as diaphragmatic dysfunction may contribute to dyspnea, recurrent infections, and increased morbidity in ESKD patients with cardiopulmonary comorbidities.

Kewords