PREVALENCE AND CHARACTERISTICS OF PRURITUS IN HEMODIALYSIS PATIENTS: RELATIONSHIP WITH QUALITY OF LIFE AND HYPERPARATHYROIDISM

 

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PREVALENCE AND CHARACTERISTICS OF PRURITUS IN HEMODIALYSIS PATIENTS: RELATIONSHIP WITH QUALITY OF LIFE AND HYPERPARATHYROIDISM

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José Fidel
Véliz Escobar
José Fidel Véliz Escobar fidelveliz@ufm.edu Hospital Universitario Nephrology Monterrey, N.L. Mexico *
Sofia López Guzmán so.guzman786@gmail.com Hospital Universitario Nephrology Monterrey, N.L. Mexico -
Kenya Yamilleth Rodríguez Ibarra kenya.rdzibarra@gmail.com Hospital Universitario Nephrology Monterrey, N.L. Mexico -
Carlos Brando González González brandoglez89@gmail.com Hospital Universitario Nephrology Monterrey, N.L. Mexico -
Rogelio de Jesús Castor Hernández rjcastorhdz@gmail.com Hospital Universitario Nephrology Monterrey, N.L. Mexico -
Ricardo Abraham Garza Treviño dr.ricardogarzat@gmail.com Hospital Universitario Nephrology Monterrey, N.L. Mexico -
Carlos Eduardo Mústieles Villa carloseduardomustieles@gmail.com Hospital Universitario Nephrology Monterrey, N.L. Mexico -
Valeria Argumedo Solís argumedovaleria07@gmail.com Hospital Universitario Nephrology Monterrey, N.L. Mexico -
Jordan Eduardo Reyna Cantú jordan.reynacn@uanl.edu.mx Hospital Universitario Nephrology Monterrey, N.L. Mexico -
José Guadalupe Ibarra Villanueva joseibarrav00@gmail.com Hospital Universitario Nephrology Monterrey, N.L. Mexico -
Martín Torres Rodríguez martin.trdz@hotmail.com Hospital Universitario Nephrology Monterrey, N.L. Mexico -
Lilia María Rizo Topete dra.liliarizo@gmail.com Hospital Universitario Nephrology Monterrey, N.L. Mexico -
Mara Cecilia Olivo Gutiérrez mara_olivo84@hotmail.com Hospital Universitario Nephrology Monterrey, N.L. Mexico -
Elisa María Guadalupe Guerrero González eguerrerog@uanl.edu.mx University Hospital Nephrology Monterrey, N.L. Mexico -
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Pruritus is a complication of chronic kidney disease (CKD) and is one of the most distressing symptoms experienced by patients undergoing hemodialysis (HD), significantly affecting their quality of life. This symptom is often underdiagnosed in HD centers, in up to 65% of cases, which prevents comprehensive patient care. It is necessary to determine the prevalence and characteristics of this symptom in the Mexican population and its impact on quality of life, in order to develop a comprehensive management protocol.

An observational, cross-sectional, and descriptive study was conducted. We studied 200 HD patients at the Regional Center for Kidney Diseases (CRER) to estimate the prevalence of pruritus. Results of complete blood count, creatinine levels, blood urea nitrogen (BUN), serum electrolytes, and intact parathyroid hormone (PTHi) were analyzed. Subsequently, the 5-D Itching Scale (5D) questionnaire, which assesses the impact of pruritus on quality of life, and the Itch Severity Scale (ISS) were administered to evaluate the intensity of pruritus.

The prevalence of pruritus in hemodialysis (HD) patients at CRER was 56%, with 112 patients experiencing it. Regarding the intensity of pruritus, assessed with the Intense Itching Scale (ISS) (Figure 1), 38.39% of patients presented very severe pruritus. Similarly, using the 5-D Itching Scale (5D) (Figure 2), the impact of pruritus on quality of life was found to be moderate in 34.82% of patients.

A strong positive correlation was observed between the two scales (r = 0.746, p < 0.001) using Pearson’s correlation, indicating that higher pruritus intensity is directly associated with lower quality of life.

Regarding the complete blood count and serum chemistry data, including electrolytes (Table 1), no direct correlation was found with itching intensity or quality of life. In contrast, when analyzing intact parathyroid hormone (PTHi) levels, values between 15–65 pg/mL were associated with mild 5-D itching, whereas levels between 301–600 pg/mL were associated with moderate 5-D itching (Table 2 and Figure 3). A chi-square test (χ² = 27.48, p = 0.025) confirmed a statistically significant association between the PTHi range and pruritus severity measured by the 5-D Itching Scale.

FIGURE 1 FIGURE 2 TABLE 1 TABLE 2 

Pruritus affects more than half of HD patients and significantly impacts their quality of life. The ISS and 5-D Itching Scale are complementary and reliable tools for evaluating pruritus intensity and its effect on daily functioning. Moreover, elevated PTHi levels appear to be related to greater pruritus severity, underscoring the importance of biochemical monitoring and comprehensive management in this population.

Kewords