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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Immunoglobulin A nephropathy (IgAN) is a common cause of glomerulonephritis that can progress to end-stage renal disease (ESRD). IgA vasculitis, a systemic small vessel vasculitis, is a recognized secondary cause of IgAN. Although rare, rapidly progressive glomerulonephritis (RPGN) can occur in the context of IgA vasculitis, with drug-induced immune responses implicated in some cases.
A 74-year-old Filipino female with no known comorbidities initially presented with flu-like symptoms two weeks prior to admission. She later developed hypogastric pain and dysuria, for which she was treated with cefuroxime 500 mg tablet twice daily for two days for urinary tract infection (UTI). Despite treatment, her symptoms worsened, progressing to generalized abdominal pain and vomiting, prompting admission. She was treated with ceftriaxone 2 g intravenously daily and was referred to nephrology for elevated creatinine (2.4 mg/dL, eGFR 21 mL/min/1.73 m2). Two days later, she developed non-blanching, non-palpable, non-pruritic, painless petechial and macular lesions on her lower extremities, accompanied with arthralgia and altered sensorium. Laboratory results revealed progressive renal dysfunction (creatinine 5.15 mg/dL, eGFR 8 mL/min/1.73 m2), proteinuria, hematuria, and oliguria, suggestive of RPGN. Renal biopsy was indicated but was deferred due to financial constraints. Ceftriaxone was discontinued, renal replacement therapy was initiated, and pulse methylprednisolone therapy followed by oral prednisone was given. A skin punch biopsy with direct immunofluorescence was done instead which confirmed IgA vasculitis.
This case illustrates an exceptionally rare presentation of RPGN secondary to IgA vasculitis in an elderly patient, with atypical non-palpable skin lesions rather than the characteristic palpable purpura. The temporal association with cephalosporin use raises the possibility of a drug-induced immune response, complicating the diagnostic process. Despite timely intervention, the patient remains hemodialysis-dependent to date.
Although rare, IgA vasculitis can progress to severe life-altering RPGN. In this case where renal biopsy was not feasible, a skin biopsy provided critical diagnostic insight. While not a substitute for renal biopsy, skin biopsy may be a valuable tool in selected vasculitis cases especially in resource-limited settings. Early intervention is critical to prevent irreversible renal damage and to improve long-term outcomes.
This abstract was also submitted in the 45th Annual Meeting of the Korean Society of Nephrology.
