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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide, with 30-40% of cases progressing to end-stage renal disease. Tonsillectomy combined with steroid pulse therapy is used to manage the IgAN-specific drivers for nephron loss in Japan. Tonsillectomy has been reported to have a favorable effect on preventing end-stage renal disease in patients with IgAN, suggesting that tonsils play an important role in the pathogenesis of IgAN. In this study, we tried to detect proteins associated with IgAN pathogenesis from four laser-microdissected regions in palatine tonsils using high-resolution mass spectrometry.
Palatine tonsil tissues were collected from patients with IgAN who received tonsillectomy and steroid pulse therapy under the prospective study protocol of Fujita Health University Hospital. The proteins of germinal center (GC), follicular mantle (FM), T-cell area (TA), and crypt epithelium (CE) were extracted from frozen palatine tonsil tissues from patients with IgAN (n=23) and controls (chronic tonsillitis, n=13) using laser microdissection. Tonsillar proteins were analyzed by label-free quantification using high-resolution mass spectrometry (Orbitrap Fusion; Thermo Fisher Scientific). Protein–protein interaction network analysis was performed using the STRING database (https://string-db.org/).
Tonsillar proteomic analysis quantified 2854, 2844, 2805 and 2782 proteins in GC, FM, TA and CE, respectively. Of those, 195 proteins in GC, 252 proteins in FM, 174 proteins in TA, and 258 proteins in CE had significantly different abundances in patients with IgAN than in the controls (FC ≥ ± 1.5, P < 0.05). The protein–protein interaction networks of significantly altered proteins revealed changes in the immune response-regulating signaling pathway within CE, the immunological synapse within GC, the innate immune response and the defense response to viruses within FM and the inflammatory response and the regulation of cytokine production within TA.
Proteomic profiling revealed changes in the immune response in the tonsils of patients with IgAN compared with those with tonsillitis. These findings may offer valuable insights for potential protein targets for modulating the immune response in IgAN.
