Renal Dysfunction Following Bothrops Snakebite: A Case Report

 

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Renal Dysfunction Following Bothrops Snakebite: A Case Report

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Poliana
Albuquerque
Davi Acselrad daviacselrad@edu.unifor.br University of Fortaleza Medicine Fortaleza Brazil -
Gabriel Parente parentegabriel@edu.unifor.br University of Fortaleza Medicine Fortaleza Brazil -
Priscila Ye Wenyan Yewenyan1@hotmail.com University of Fortaleza Medicine Fortaleza Brazil -
Isis Batista isisbatistaholanda@edu.unifor.br University of Fortaleza Medicine Fortaleza Brazil -
André Mota dedecmota09@gmail.com University of Fortaleza Medicine Fortaleza Brazil -
João Saraiva jpmsaraiva@edu.unifor.br University of Fortaleza Medicine Fortaleza Brazil -
André Santos andreliborio@edu.unifor.br University of Fortaleza Medicine Fortaleza Brazil -
Leticia Santos leticialiboriosantos@edu.unifor.br University of Fortaleza Medicine Fortaleza Brazil -
Lucas Mota lucasbraga3@gmail.com University of Fortaleza Medicine Fortaleza Brazil -
Júlia Dantas julia.cambraiad@gmail.com University of Fortaleza Medicine Fortaleza Brazil -
Marcelo Filho marceloleitefer@gmail.com University of Fortaleza Medicine Fortaleza Brazil -
Erick Mota erickfeitosa03@edu.unifor.br University of Fortaleza Medicine Fortaleza Brazil -
Elizabeth Daher ef.daher@uol.com.br Federal University of Ceará Medicine Fortaleza Brazil -
Poliana Albuquerque polianna.albuquerque@cdu.edu.au Charles Darwin University Medicine Darwin Australia *
Geraldo Junior geraldobsilvajr@yahoo.com University of Fortaleza Medicine Fortaleza Brazil -

Snakebite envenoming is a major tropical health problem, with Bothrops species responsible for most cases in Brazil. Acute kidney injury (AKI) is one of the most severe complications, linked to delayed treatment and pre-existing comorbidities. The Bothrops venom contains proteolytic, coagulant, and nephrotoxic components that can trigger renal tubular necrosis, microangiopathy, and rhabdomyolysis.

Case report: A 56-year-old male farmer with systemic hypertension was bitten on the right foot by Bothrops jararaca. He sought medical care three days later with oliguria and generalized edema. Laboratory results showed creatinine 10.20 mg/dL,


urea 234 mg/dL, sodium 131 mEq/L, potassium 4.2 mEq/L, leukocytes 12 540/mm³, and platelets 310 000/mm³. He received antivenom, antibiotics, and tetanus prophylaxis. Hospitalization lasted 48 days, during which he required 20 sessions of intermittent hemodialysis. Serum creatinine declined to 2.3 mg/dL at discharge, with subsequent normalization under nephrological follow-up 

Snakebites affect 5.4 million people worldwide annually, causing up to 138 000 deaths. The venom’s proteolytic and coagulant actions lead to local inflammation, coagulopathy, and systemic effects, including renal dysfunction. AKI is reported in 20–25% of Bothrops accidents and is a leading cause of death. Risk factors include comorbidities such as hypertension and delayed access to care. In this case, the three-day delay before antivenom administration likely aggravated renal injury. Despite the severity, progressive renal recovery after 20 dialysis sessions demonstrates the potential


reversibility of Bothrops-induced AKI when appropriate nephrological care is provided.

Studies from the Brazilian Amazon show a 13 % incidence of AKI after Bothrops envenoming and strong associations with systemic bleeding and elevated LDH. The patient’s hypertension and late admission were probably decisive in the evolution toward severe AKI. Long-term follow-up remains crucial, as chronic kidney disease may develop after apparent recovery.

This case underscores the importance of early diagnosis and antivenom administration in Bothrops envenoming to prevent AKI and reduce mortality. Prompt referral to specialized nephrology centers and continued outpatient monitoring are essential. Early recognition and public health measures remain key to reducing the burden of this neglected tropical disease.

 

 

 

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