EPIDEMIOLOGICAL PROFILE OF HOSPITALIZATIONS DUE TO TUBULOINTERSTITIAL KIDNEY DISEASES IN BRAZIL: ANALYSIS BY GENDER AND REGION (2015–2025)

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EPIDEMIOLOGICAL PROFILE OF HOSPITALIZATIONS DUE TO TUBULOINTERSTITIAL KIDNEY DISEASES IN BRAZIL: ANALYSIS BY GENDER AND REGION (2015–2025)

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Co-author 1

Davi Acselrad daviacselrad@edu.unifor.br University of Fortaleza Medicine Fortaleza Brazil -

Co-author 2

Gabriel Parente parentegabriel@edu.unifor.br University of Fortaleza Medicine Fortaleza Brazil -

Co-author 3

Marcelo Filho marceloleitefer@gmail.com University of Fortaleza Medicine Fortaleza Brazil -

Co-author 4

Tiago Maia tiagocmaiaa@gmail.com University of Fortaleza Medicine Fortaleza Brazil -

Co-author 5

João Saraiva jpmsaraiva@edu.unifor.br University of Fortaleza Medicine Fortaleza Brazil -

Co-author 6

Isis Holanda isisbatistaholanda@edu.unifor.br University of Fortaleza Medicine Fortaleza Brazil -

Co-author 7

Elizabeth Daher ef.daher@uol.com.br Federal University of Ceara Medicine Fortaleza Brazil -

Co-author 8

Poliana Albuquerque polianna.albuquerque@cdu.edu.au Charles Darwin University Medicine Darwin Australia -

Co-author 9

Erick Mota erickfeitosa03@edu.unifor.br University of Fortaleza Medicine Fortaleza Brazil -

Co-author 10

Priscila Ye Wenyan Yewenyan1@hotmail.com University of Fortaleza Medicine Fortaleza Brazil -

Co-author 11

André Mota dedecmota09@gmail.com University of Fortaleza Medicine Fortaleza Brazil -

Co-author 12

Geraldo Junior geraldobsilvajr@yahoo.com University of Fortaleza Medicine Fortaleza Brazil *

Co-author 13

Co-author 14

Co-author 15

Introduction

Tubulointerstitial kidney diseases (TKD) comprise a group of disorders with similar patterns of tubular and interstitial injury, commonly caused by excessive exposure to toxins, drugs, or infections. The main categories include acute tubular necrosis and acute or chronic tubulointerstitial nephritis, the latter accounting for about 20% of acute kidney injury (AKI) cases. This study aimed to analyze the epidemiological profile of hospitalizations for tubulointerstitial kidney diseases in Brazil from 2015 to 2025.

Methods

This was a cross-sectional, documentary, and quantitative study using data from the Department of Informatics of the Unified Health System (DATASUS) on hospital admissions for tubulointerstitial kidney diseases in each Brazilian region between 2015 and 2025, with emphasis on gender distribution.

Results

A total of 660,555 hospitalizations for tubulointerstitial kidney diseases were recorded nationwide. Females accounted for 67.9% (n=448,545) and males for 32.1% (n=212,010). By region, the Southeast had the highest number of admissions: 32.3% (n=212,968), followed by the Northeast 25.7% (n=169,641), South 22.4% (n=147,911), North (11%; n=72,608), and Center-West 8.7% (n=57,427).

Conclusion

This study revealed the regional distribution of hospitalizations for tubulointerstitial kidney diseases in Brazil, highlighting a predominance in the Southeast region and among females. The higher concentration in the most populous region suggests that sociodemographic factors may influence both diagnosis and access to treatment. Moreover, the predominance of hospitalizations among women may be explained by greater healthcare-seeking behavior, a higher prevalence of autoimmune diseases, and hormonal factors that predispose to urinary tract and renal disorders.

Kewords