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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Urosepsis is a severe condition and a major driver of morbidity and mortality in patients with chronic kidney disease (CKD). The most frequent germs involved are E. coli (50%), Klebsiella pneumoniae (15%), and Proteus spp. (15%), but atypical pathogens are increasingly recognized.
Atypical pathogens involved in urosepsis exhibit unique virulence mechanisms that differentiate them from classic uropathogens, often contributing to delayed diagnosis, increased severity, and resistance to conventional treatments. Their clinical significance remains underexplored.
Aim. To evaluate the clinical profile, microbial spectrum and outcomes in patients with urosepsis due to atypical pathogens in a tertiary nephrology center from Southeastern Romania.
Observational (prospective and retrospective) study based on medical papers and electronic medical records of patients diagnosed with urosepsis, admitted to the Nephrology Clinic of the County Emergency Clinical Hospital of Constanta between 2020-2024. Atypical germs were defined as non-classical uropathogens with recognized pathogenic potential.
Out of the total of 300 patients with urosepsis, 37 had atypical germs isolated in urine/blood culture (12.33%). The mean age was 67.72 ± 8.48 years (57.6% female, 42.4% male) and over half had advanced CKD, including 31% on hemodialysis. More than 50% of the isolated atypical germs were gram-negative (e.g., Myroides, Providencia rettgeri, Citrobacter freundii, Serratia fonticola, Aeromonas caviae, Klebsiella rhinoscleromatis), 45% were gram-positive bacteria (e.g.,Enterococcus casseliflavus, Raoultella ornithinolytica, Enterococcus galinarum). Multi–drug resistance was found only in 9% of urine cultures.
Significant comorbidities including cognitive impairment, malnutrition, obesity, and diabetic nephropathy are associated with urosepsis caused by atypical pathogens (p < 0.05).
However, prolonged urinary catheterization was not associated with infection by atypical organisms (p = 0.58).
Atypical pathogens in urosepsis are underestimated, but clinically relevant in advanced CKD and dialysis populations. They are associated with frailty-related comorbidities, but urinary catheters may not be a strong predictor of infection by these types of bacteria in our data. Atypical germs maintain sensitivity to a wide range of antibiotics, making them manageable with appropriate treatment.
Broader awareness of these pathogens may target diagnostic and therapeutic strategies worldwide.
