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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Zinc deficiency is widely observed in patients with chronic kidney disease (CKD). Several studies show association between zinc deficiency and aortic calcification in patients with CKD. However, there are few studies to investigate the longitudinal association between zinc deficiency and vascular calcification, especially in patients with CKD. Therefore, we investigated longitudinal associations between serum zinc (s-Zn) levels and aortic arch calcification (AAC) in patients with incident dialysis.
We retrospectively analyzed data from patients with CKD who started dialysis at our hospital between January 2013 and August 2023. Inclusion criteria were (1) no visible AAC on chest X-ray at the time of dialysis initiation, (2) patients in whom chest X-ray could be followed, and (3) patients who did not opt out from this study. We excluded patients who were supplemented with zinc or who were not measured laboratory data including serum zinc at the time of dialysis initiation. We evaluated newly detected AAC on chest X-ray within 2 years. Study participants were stratified into tertiles of serum zinc level: low group (s-Zn < 46 μg/dL), intermediate group (s-Zn 46 – 54 μg/dL) and high group (s-Zn > 54 μg/dL). This study was performed according to the Ethical Guidelines for Medical and Health Research Involving Human Subjects established by the Ministry of Health, Labor, and Welfare (Japan) and the Institutional Review Board of Kasugai Municipal Hospital. The institutional review board at our hospital approved the study protocol (approval no. 221).
Of the 233patients analyzed, 65 (27.9%) had newly detected AAC. The rate of AAC was significantly higher in patients with low s-Zn than those with high s-Zn (p = 0.002) (Figure 1). In multivariate analysis adjusted for baseline data including age, sex, BMI, smoking, systolic blood pressure, co-existence of DM, history of CVD, dialysis modality, current medication and laboratory data, low s-Zn level (s-Zn < 46 μg/dL) was independently associated with newly detected AAC [OR 2.91 (95% CI 1.10 – 7.65), p = 0.031)] (Figure 2). Addition to s-Zn level in a model with baseline data improved the C-index (0.744 to 0.761, p = 0.010), net reclassification improvement (NRI) (0.328, p = 0.012) and integrated discrimination improvement (IDI) (0.022, p = 0.012).
Low s-Zn level was independently associated with newly detected AAC, which indicates that low s-Zn predicts vascular calcification development in patients with incident dialysis.
