Uric Acid Encrustation Due to Prolonged Ureteral Stent Retention: A Cautionary Tale After Kidney Transplantation

 

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Uric Acid Encrustation Due to Prolonged Ureteral Stent Retention: A Cautionary Tale After Kidney Transplantation

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Haruka
Maruyama
Haruka Maruyama harukamaruyama5@gmail.com Tokyo Nishi Tokushukai Hospital Division of Nephrology Kamakura Japan *
Keita Okubo keitaokubo2000@gmail.com Shonan Kamakura General Hospital Department of Kidney Transplantation Kamakura Japan -
Kazunari Tanabe kaunaritanabe0323@gmail.com Shonan Kamakura General Hospital Department of Kidney Transplantation Kamakura Japan -
Sumi Hidaka s_hidaka@shonankamakura.or.jp Shonan Kamakura General Hospital Kidney Disease and Transplant Center Kamakura Japan -
Shuzo Kobayashi shuzo@shonankamakura.or.jp Shonan Kamakura General Hospital Kidney Disease and Transplant Center Kamakura Japan -
 
 
 
 
 
 
 
 
 
 

Ureteral stents are placed to prevent urinary leakage after kidney transplantation. However, prolonged indwelling increases the risk of crystal deposition and encrustation, potentially leading to obstruction and graft dysfunction.

A 50-year-old man with end-stage kidney disease secondary to IgA nephropathy underwent living donor kidney transplantation. A double-J ureteral stent was placed intraoperatively and removed on postoperative day (POD) 16. On POD 23, he developed a perinephric hematoma requiring surgical evacuation. Due to dense adhesions, the ureter was injured during the procedure, necessitating stent replacement. Following treatment for T cell–mediated rejection and evacuation of the hematoma, the stent remained in place. On POD 120, he presented with right lower abdominal pain and brownish, sand-like urine sediment. Stone analysis revealed uric acid crystals. Non-contrast CT showed hydronephrosis of the transplanted kidney without radiopaque stones, and his serum creatinine was elevated. 

Multiple attempts at stent removal and two sessions of extracorporeal shock wave lithotripsy failed, so a percutaneous nephrostomy was placed, leading to recovery of graft function. After 40 days of urinary alkalization with potassium citrate and sodium citrate hydrate, the encrusted stent was successfully removed, and graft function remained stable.

This case demonstrates a rare but serious complication of kidney transplantation: uric acid encrustation of a long-term indwelling ureteral stent. Non-surgical management with urinary alkalization effectively dissolved the uric acid deposits, allowing safe stent removal and preservation of graft function. After discontinuing dialysis, the patient relaxed dietary restrictions and began consuming more meat, leading to Increased purine intake, urine acidification and uric acid crystal formation. This case emphasizes the importance of timely stent management, regular monitoring, and awareness of complications associated with delayed stent removal in kidney transplant recipients.

Kewords