The effect of Fib-4 marker on chronic kidney disease; examination of the disease course in middle-aged and elderly patients with chronic kidney disease

 

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The effect of Fib-4 marker on chronic kidney disease; examination of the disease course in middle-aged and elderly patients with chronic kidney disease

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Sibel
Gökcay Bek
Zafer Burak Cende b.cande@gmail.com Kocaeli University Internal Medicine Kocaeli Turkey -
Sibel Gökcay Bek beksibel@gmail.com Kocaeli University Nephrology Kocaeli Turkey *
Sibel Balcı b.s.balci@gmail.com Kocaeli University Department of Biostatistics and Medical Informatics Kocaeli Turkey -
Metin Ergul dr.metinergul@gmail.com Kocaeli University Nephrology Kocaeli Turkey -
Ali Erkan Duman erkan.duman@kou.edu.tr Kocaeli University Gastroenterology Kocaeli Turkey -
Erkan Dervisoglu erkandervisoglu@gmail.com Kocaeli University Nephrology Kocaeli Turkey -
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Chronic kidney disease (CKD) and hepatic steatosis are two important clinical conditions that are frequently observed together, often in association with metabolic syndrome, and they contribute significantly to the global health burden. The FIB-4 index is a widely used non-invasive marker for assessing liver fibrosis, and its systemic implications have been investigated in recent years. The objective of this research was to assess the connection between FIB-4 and kidney function.

This prospective cohort study included 316 patients diagnosed with CKD and hepatic steatosis. Patients were divided into four groups (A–D) based on their FIB-4 scores. Using three-year follow-up data, the annual percentage changes in eGFR, liver enzymes, and hematological and metabolic parameters were calculated. These changes were first compared between groups, and Spearman’s correlation analysis was used to assess the relationships between variables across the entire cohort.

No significant differences were observed in eGFR values between the FIB-4 groups. However, Spearman’s correlation analysis revealed a weak but statistically significant negative correlation between FIB-4 and eGFR (r = -0.126, p = 0.025). FIB-4 was positively correlated with AST and AST/ALT ratio and negatively correlated with platelet count. No significant association was found between FIB-4 and ferritin, erythrocyte sedimentation rate, or liver size.

The modest yet noteworthy inverse relationship between FIB-4 and eGFR indicates that liver fibrosis might indirectly affect kidney function. Nevertheless, the FIB-4 index seems to be a limited indicator for predicting the progression of kidney disease. More extensive and prolonged studies are necessary to better understand this connection.

Kewords