OUTCOMES OF RENAL TRANSPLANTATION IN AFRICA A SYSTEMATIC REVIEW AND META-ANALYSIS

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OUTCOMES OF RENAL TRANSPLANTATION IN AFRICA A SYSTEMATIC REVIEW AND META-ANALYSIS

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Co-author 1

Bekalu Mekonen Belay bekalumekonen20@gmail.com Debre Tabor University Department of adult health nursing Debre Tabor Ethiopia *

Co-author 2

Yirgalem Abere yirgalemabere123@gmail.com Debre Tabor University Department of adult health nursing Debre Tabor Ethiopia -

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Introduction

Background: Despite, transplantation is considered the recommended course of treatment for end-stage renal disease; data on post-transplant outcomes remains fragmented in Africa.

Methods

Objective: This study aims to assess outcomes of renal transplantation in Africa.

Design: Studies were searched in MEDLINE, EMBASE, CINAHL, Scopus, Google Scholar, the Transplantation library, and African Journal Online. A random-effects model was employed to calculate the pooled effect size of each outcome. Heterogeneity was assessed with the I² test, and publication bias was evaluated using Egger's regression test. Trim and fill analysis was employed to manage publication bias. The protocol has been registered in an international prospective register of systematic reviews (PROSPERO) under the ID CRD42025642706.

Studies: studies conducted in Africa.

Participant: In this study, 16 articles were included with a total of 3617 population.

Results

Result: Pooled mortality of renal transplant recipients was 14.3% (95 CI 8.77% -19.84%). Graft survival rates at one, and five years were 91.74% and 69.15% respectively. While patient survival at one, and five years were 94.72%, and 81.26% respectively. Diabetes mellitus, delayed graft function, acute rejection and infection were isolated post-transplantation complications.

Conclusion

Conclusion: Few important exceptions, both graft and patient survival were comparable with reports from other nations. Thus, we recommend that clinical practitioners prioritize infection prevention and early screening of complications. Furthermore, the policymakers shall develop and implement strategies to prevent, screen post-transplant complications. As well as work on accessibility of the service.

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