Back
For best output, select "Paper Size" as "A4" and "Margin" as "0" or "None".
To save or print to PDF, please select Print Destination > Save as PDF, enable Background Graphics under "More Settings", then click "Save".
During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Renal hyperfiltration (RHF) has been associated with mortality in several studies from various cohort groups which is estimated by the estimated glomerular filtration rate (eGFR) based on CKD-EPI equation. However, definition of RHF is not established and researchers have used various criterion for RHF. Furthermore, the association between higher eGFR and mortality is remained to be confirmed in elderly population, especially in population aged more than 75 years. We searched the significance of higher eGFR on all-cause mortality in patients aged 65 to 74 years (elderly group) and in population aged ≥ 75 years (elderly elder group).
This retrospective cohort study included 6,118 individuals aged ≥ 65 years having serum creatinine test who underwent comprehensive geriatric assessment at a university hospital in Korea between January 2016 and December 2020. Participants with eGFR of more than 15 ml/min/1.73m² estimated by CKD-EPI equation and at least three months of follow-up were included. We grouped participants by eGFR as follows; G1; eGFR ≥ 90, G2; 75-89, G3; 60-74, G4; 45-59, and G5; < 45 ml/min/1.73 m2.
There were 2750 (44.9 %) male participants. Mean age was 78.7 ± 6.0 (range: 65.0-104.8) years and mean eGFR was 75.8 ± 19.4 ml/min/1.73 m2. During 43.1 ± 21.4 months of mean follow-up period, there were 2,117 mortalities (34.6 %). Mortality rates were 33.6 % (460/1370) in G1, 29.8% (721/2421) in G2, 32.0% (353/1103) in G3, 42.5 % (290/682) in G4, and 54.1 % (293/542) in G5 (p<0.001). AUC by ROC analysis showed increased risk of mortality with decrease of eGFR (AUC= 0.556, 95% CI: 0.540-0.574, p<0.001).
In whole participants, hazard ratio (HR) was 0.974 (95% CI: 0.952-0.998, p=0.032) to estimate mortality by increase of eGFR 10 ml/min/1.73m² calculated with Cox’s hazard proportional model adjusted by related factors to mortality. The group of eGFR was also a significant risk factor to mortality (p=0.007). Risk of mortality was increased in G3 (HR 1.155, p=0.040), G4 (HR 1.233, p=0.006), and G5 (HR 1.277, p=0.002) subgroups compared to G2 subgroup. Risk of mortality in G1 subgroup was not higher compared to that of subgroup G2 in whole participants (p=0.055).
However, in elderly elder participants, HR for mortality were 1.176 (95% CI; 1.013-1.364, p=0.033) in G1 subgroup compared to G2 subgroup (Figure). Risk of mortality was increased in G4 subgroup (HR 1.222, p=0.014) and G5 subgroup (HR 1.288, p=0.002), not in G3 subgroup (p=0.057), compared to G2 subgroup.
The finding that patients with higher eGFR had higher risk of mortality compared to patients with eGFR 75-89 ml/min/1.73 m2 was also evident in males, patients without diabetes mellitus, normotensive patients whereas, and patients with lesser comorbidities defined as Charlson’s Comobidity index (CCI). it was not observed in females, patients with diabetes mellitus, hypertensive patients, and patients with CCI ≥ 3.
Mortality risk was increased in patients with eGFR < 75 ml/min/1.73 m2 in elder population compared to that of patients with eGFR 75-89 ml/min/1.73 m2. Furthermore, elderly elder patients with eGFR ≥ 90 ml/min/1.73 m2 had higher risk of mortality compared to patients with eGFR 75-89 ml/min/1.73 m2, that was not evident in elder patients with age between 65-74 years.
