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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Kidney fibrosis is a common mechanism of progressive kidney diseases including diabetic kidney disease (DKD). We have revealed palladin, an actin-associated protein, promotes kidney fibrosis through actin cytoskeleton-dependent myocardin-related transcription factors (MRTF)-serum response factor (SRF) signaling. However, it has not been elucidated whether palladin is related to the pathogenesis of DKD. In this study, we investigated whether palladin is associated with kidney dysfunction, fibrosis, and kidney prognosis in DKD.
We conducted a retrospective cohort study of Japanese patients diagnosed with DKD by kidney biopsy between 2000 and 2020 at Kanazawa University. Palladin expression was quantified as the percentage of positive area on immunohistochemistry. We assessed its correlation with baseline eGFR, interstitial fibrosis and tubular atrophy (IFTA) score. The severity of IFTA was evaluated semiquantitatively according to the pathological classification by the Renal Pathology Society as follows: score 0, no IFTA; score 1, < 25 %; score 2, 25–50 %, and score 3, >50 %. Kidney event-free survival was analyzed by Kaplan-Meier and compared by log-rank test. A kidney event was defined as a ≥50% decline in eGFR or initiation of renal replacement therapy.
A total of 38 patients were enrolled with a mean age of 57.4 years (26.3% female) and a mean eGFR of 53.2 mL/min/1.73 m². Median follow-up was 1.4 years (range 0.01–19.9), during which 14 patients (36.8%) experienced a kidney event. On immunohistochemistry, palladin localized predominantly to the kidney interstitial space. Palladin-positive area correlated inversely with eGFR (Pearson’s correlation coefficient r = –0.42; p = 0.008) and positively with IFTA score (Spearman’s rank correlation coefficient ρ = 0.41; p = 0.011). Patients with higher palladin-positive area had a significantly increased risk of kidney events (log-rank p = 0.038).
Interstitial palladin expression may serve as a prognostic marker in patients with DKD. Prospective validation in larger, multicenter cohorts is warranted.
