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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
The Naples Prognostic Score (NPS) is based on inflammatory markers and nutritional status. It was first proposed by Garzia et al. in a colorectal cancer study. To date, the prognostic significance of this score has been validated in various cancers: neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), serum albumin, and total cholesterol. NLR and LMR reflect the balance of inflammatory and immune responses, while albumin and cholesterol serve as surrogates for nutritional status and lipid metabolism—both critical in sepsis pathophysiology. Although NPS has demonstrated prognostic value in cancers, its role in Sepsis-associated acute kidney injury (SA-AKI) remains uninvestigated.
This study aims to evaluate the predictive efficacy of NPS in SA-AKI and explore its mechanistic link to renal injury, with the goal of providing a novel clinical tool for early SA-AKI risk assessment.
This single-center, retrospective cohort study was conducted in the Intensive Care Unit of the First Affiliated Hospital of Soochow University from May 2023 to May 2024. 81 sepsis patients were included, with 37 cases in the SA-AKI group and 44 in the non-AKI group. One-way ANOVA was applied to variables exhibiting normal distribution and homo-geneous variance. Spearman analysis was performed to assess relationships. Binary and ordered logistic regression analyses were conducted to evaluate independent relationships with SA-AKI. Receiver operating characteristic (ROC) curve was employed to determine diagnostic accuracy. The survival curve was plotted by Kaplan Meier.
The NPS score was significantly higher in the SA-AKI group than in the non-AKI group (P<0.001). Multivariate logistic regression showed that NPS was an independent predictor of SA-AKI (OR = 11.777, P<0.001), with an area under the ROC curve (AUC) of 0.855. Correlation analysis indicated positive associations of NPS with renal injury markers (urea nitrogen, serum creatinine, cystatin C) and negative associations with platelet count and low-density lipoprotein. Subgroup analyses demonstrated that NPS effectively predicted SA-AKI regardless of vasopressor use or continuous renal replacement therapy (CRRT), with AUC values of 0.898 in the vasopressor group and 0.866 in the non-CRRT group.
NPS serves as an independent predictor of SA-AKI, integrating inflammatory, nutritional, and metabolic markers to provide new insights into SA-AKI pathophysiology. Clinically, NPS offers a simple and feasible tool for early identification of high-risk SA-AKI patients, guiding personalized treatment strategies.
