CUTANEOUS MANIFESTATIONS IN RENAL TRANSPLANT RECIPENTS: A SINGLE CENTER, CROSS-SECTIONAL STUDY IN THAILAND

 

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https://storage.unitedwebnetwork.com/files/1099/8ae166b3dd43dcef7b6571b6ddf3c465.pdf
CUTANEOUS MANIFESTATIONS IN RENAL TRANSPLANT RECIPENTS: A SINGLE CENTER, CROSS-SECTIONAL STUDY IN THAILAND

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Supapat
Laodheerasiri
Supapat Laodheerasiri l.supapat@pcm.ac.th Phramongkutklao hospital Medicine Bangkok Thailand *
Krittin Sowphitakwattana krittin_man_u@hotmail.com Phramongkutklao hospital Medicine Bangkok Thailand -
Pitchamon Inkong beaupitchamon@gmail.com Phramongkutklao hospital Medicine Bangkok Thailand -
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Long-term immunosuppression in renal transplant recipients (RTRs) causes various skin manifestations, ranging from cosmetic conditions to severe infections and malignancies.

A cross-sectional descriptive study was conducted at Phramongkutklao Hospital from January 1, 2014, to December 31, 2024, involving 260 RTRs.

The median age of the 260 RTRs was 47 years (range: 18–79). Immunosuppressive regimens included calcineurin inhibitors, azathioprine, mycophenolate mofetil/mycophenolic acid, cyclosporine, and prednisolone. A total of 195 cutaneous manifestations were identified, excluding xerosis and scars. Viral infections (18.1%) were the most common, including herpes zoster (8.8%), herpes simplex (6.5%), and warts (5%). Fungal infections (16.2%) included pityrosporum folliculitis (7.3%), dermatophytes (5.4%), and pheohyphomycosis (0.8%). Drug-induced acneiform eruptions were observed in 11.2%. Herpes zoster occurred at a median of 798 days (range: 32–10,045), with 78.3% of cases occurred after the first year after transplantation. Graft rejection (41.15%) significantly increased herpes zoster prevalence (15.9% vs. 3.9%, p = 0.001). Prednisolone dosages 20 mg/day correlated with significantly higher prevalence of herpes zoster (30% vs. 8%, p < 0.05), dermatophytes (20% vs. 4.8%, p < 0.05), pityrosporum folliculitis (50% vs. 5.6%, p < 0.001), and acneiform eruptions (50% vs. 5.6%, p < 0.001).

Skin conditions are prevalent in RTRs, particularly after the first-year post-transplant. Associations between graft rejection, high-dose prednisolone, and herpes zoster warrant further study.

Kewords