Back
For best output, select "Paper Size" as "A4" and "Margin" as "0" or "None".
To save or print to PDF, please select Print Destination > Save as PDF, enable Background Graphics under "More Settings", then click "Save".
During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Although the use of continuous renal replacement therapy (CRRT) in pediatric patients is increasing, large-scale evidence on major adverse kidney events (MAKE), a composite outcome of death, new dialysis dependency, and persistent kidney dysfunction, is scarce. This evidence gap contributes to significant variability in clinical practice. This study aimed to determine the incidence and identify factors independently associated with MAKE at pediatric intensive care unit (PICU) discharge among children undergoing CRRT using data from the Japanese Pediatric CRRT Registry (jpCRRT registry).
We conducted a multicenter observational study between January 2023 and August 2025. The study included patients aged < 16 years who underwent CRRT for acute illness in the PICU. Patients undergoing chronic maintenance dialysis were excluded. We used multivariable logistic regression analysis to identify factors independently associated with MAKE at PICU discharge. Missing data were handled using multiple imputations. Variables for the model were selected based on least absolute shrinkage and selection operator regression and previously reported clinically significant factors, and the results were pooled using Rubin's Rule.
In total, 139 patients were included. The cohort consisted of 63% males, with a median age of 13 (interquartile range [IQR], 0–69) months. Thirty-one percent had congenital heart disease, and the median pediatric Sequential Organ Failure Assessment score was 9 (IQR, 5–12). The median pre-CRRT Vasoactive-Inotropic Score (VIS) was 5 (IQR, 0–13). The primary indications for CRRT were fluid overload (63%) and acid-base disturbances (55%). The modalities used were continuous hemodialysis (69%) and hemodiafiltration (31%). Concomitant extracorporeal membrane oxygenation was used in 32% of cases. The incidence of MAKE at PICU discharge was 55%, comprising 18% mortality, 13% new dialysis dependence, and 37% persistent kidney dysfunction. The factors independently associated with MAKE were sepsis and renal disease as reasons for PICU admission, pre-CRRT serum potassium levels, and the VIS (Table 1).
The incidence of MAKE in the jpCRRT registry cohort was remarkably high. Furthermore, it suggests that beyond kidney disease, sepsis, high vasopressor requirements, and hyperkalemia are important markers of MAKE, underscoring the need for multidisciplinary care.
