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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Early intervention is essential for improving the prognosis of chronic kidney disease (CKD). Growing evidence indicates that even mild reductions in estimated glomerular filtration rate (eGFR) are linked to adverse kidney outcomes. However, the specific impact of subnormal eGFR (60–90 mL/min/1.73 m²) on mortality in older adults and the factors shaping individual susceptibility remain unclear. Central obesity may impair energy balance and metabolic regulation, reducing the body’s adaptability to kidney dysfunction. This study aims to examine the association between subnormal eGFR and mortality in older adults, with a focus on the sex-specific modifying effects of different obesity metrics.
A total of 136,028 elderly participants with baseline subnormal eGFR (60–90 mL/min/1.73 m²) were identified from the UK Biobank. Fixed-effects Cox regression models were used to assess both the linear and nonlinear associations between changes in subnormal eGFR and mortality. To quantify how obesity modifies adaptability to subnormal eGFR, tensor product interaction functions were applied to model the joint effects of eGFR changes and obesity metrics, presented as two-dimensional exposure–response functions (ERFs). Three obesity indicators, including waist circumference (WC), body mass index (BMI), and waist-to-height ratio (WHtR), were analyzed.
Participants had a mean age of 59.5 ± 7.2 years. Over a median follow-up of 14.7 years (interquartile range: 13.8–15.4 years), 12,396 deaths occurred. Based on the fully-adjusted model, each 10-unit decrease in eGFR was associated with an excess mortality risk of 9.1% (95% confidence interval 6.6%–11.7%). The effects of subnormal eGFR on mortality differed by obesity metrics, with significant synergistic interactions observed for central obesity indicators (WC and WHtR). Two-dimensional ERFs demonstrated that individuals with higher central obesity exhibited a forward shift in mortality risk thresholds, reflecting reduced adaptability to mild declines in eGFR.
Subnormal eGFR was associated with elevated mortality in older adults, with risks more pronounced in those with greater central obesity. These findings underscore the importance of early intervention for subnormal eGFR and enhanced obesity management to improve resilience against kidney dysfunction in aging populations.
