PREDICTIVE ACCURACY OF THE SIMPLE POSTOPERATIVE AKI RISK (SPARK) CLASSIFICATION FOR POSTOPERATIVE ACUTE KIDNEY INJURY IN ADMITTED ADULT FILIPINO GENERAL SURGICAL PATIENTS IN A TERTIARY HOSPITAL

 

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https://storage.unitedwebnetwork.com/files/1099/a6e6afdecf52d4e4180ee5994a5a9692.pdf
PREDICTIVE ACCURACY OF THE SIMPLE POSTOPERATIVE AKI RISK (SPARK) CLASSIFICATION FOR POSTOPERATIVE ACUTE KIDNEY INJURY IN ADMITTED ADULT FILIPINO GENERAL SURGICAL PATIENTS IN A TERTIARY HOSPITAL

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Joanna Raphaelle
Gaña
Joanna Raphaelle Gaña jrcgana@gmail.com Cardinal Santos Medical Center Section of Nephrology, Internal Medicine Department San Juan City Philippines *
Kristian Anteolin Punsalan kadp1026@yahoo.com Cardinal Santos Medical Center Section of Nephrology, Internal Medicine Department San Juan City Philippines -
 
 
 
 
 
 
 
 
 
 
 
 
 

Postoperative acute kidney injury (PO-AKI) is a frequent complication of major surgery, associated with prolonged hospitalization, higher costs, and increased mortality. Accurate preoperative risk stratification is essential for prevention and early intervention. The Simple Postoperative AKI Risk (SPARK) classification, developed in South Korea, uses common clinical and laboratory variables to estimate risk in non-cardiac surgery patients and has shown good performance in its derivation cohorts. However, external validations have reported variable accuracy, raising concerns about its generalizability across different populations. Given the distinct demographic and clinical profiles of Filipino surgical patients, this study evaluated the predictive accuracy of SPARK for PO-AKI in this setting and explored alternative predictors to optimize local risk estimation.

A retrospective cohort study was conducted on 200 adults who underwent general surgery between January 2020 and December 2024. PO-AKI was defined by Kidney Disease: Improving Global Outcomes (KDIGO) criteria within 7 days postoperatively. Patients were stratified into SPARK risk classes A–D. Discriminative performance was assessed using sensitivity, specificity, predictive values, likelihood ratios, and the area under the receiver operating characteristic curve (AUC). Calibration was evaluated through Hosmer-Lemeshow testing and decile-level analyses. Multivariable logistic regression was performed on modified SPARK variables, substituting serum creatinine for estimated glomerular filtration rate (eGFR), to identify independent predictors of PO-AKI.

Figure 1. ROC curve comparison: recalibrated model vs. original SPARK score

The cohort had a median age of 61 years, and 51% were male. PO-AKI occurred in 8.6% of patients, with incidence rising progressively across SPARK classes (3.4% in Class A, 12.3% in Class B, 19.7% in Class C, 31.8% in Class D; trend p=0.0038). Five patients (2.5%) required dialysis, limited to Classes C and D. The SPARK classification showed poor discrimination (AUC=0.689) and risk overestimation in higher strata, with sensitivities of 3–47% and specificities of 62–91%. Positive predictive values were low (3–32%), while negative predictive values remained high (82–86%). Calibration analysis showed modest agreement between predicted and observed risks. In multivariable analysis, hypoalbuminemia (adjusted OR 0.33; 95% CI 0.14–0.78; p=0.011) and anemia (adjusted OR 6.85; 95% CI 1.21–38.75; p=0.029) were independent predictors of PO-AKI. A modified model incorporating these variables achieved superior discrimination (AUC=0.83) and excellent calibration (Hosmer-Lemeshow p=0.67) (Figure 1).

The SPARK classification demonstrated limited utility in this Filipino surgical cohort due to poor discrimination and risk overestimation. Incorporating locally relevant predictors, particularly serum albumin and hemoglobin, improved predictive performance. These findings highlight the need for local recalibration of risk tools and support the integration of simple laboratory parameters for targeted perioperative interventions to mitigate PO-AKI risk.

Kewords