EXPLORING THE BURDEN OF PROTEIN-ENERGY WASTING AMONG PATIENTS WITH END-STAGE KIDNEY DISEASE RECEIVING HEMODIALYSIS AND PERITONEAL DIALYSIS

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Abstract Title *

EXPLORING THE BURDEN OF PROTEIN-ENERGY WASTING AMONG PATIENTS WITH END-STAGE KIDNEY DISEASE RECEIVING HEMODIALYSIS AND PERITONEAL DIALYSIS

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Co-author 1

Piyarat Rojsanga piyarat099@cpird.in.th Udon Thani Hospital Medicine Udon Thani Thailand *

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Introduction

Patients with chronic kidney disease, particularly those with end-stage kidney disease (ESKD) receiving dialysis, frequently experience protein-energy wasting (PEW). The prevalence of PEW in Thai dialysis patients is not well documented. This study was conducted to determine the prevalence of PEW in ESKD patients receiving dialysis and the risk factors associated with this condition.

Methods

This cross-sectional study collected data from ESKD patients undergoing either peritoneal dialysis or hemodialysis at Udon Thani Hospital between June 30, 2024, and February 28, 2025. PEW was evaluated according to the criteria established by the International Society of Renal Nutrition and Metabolism (ISRNM). Potential risk factors associated with PEW were examined using multivariable logistic regression analysis, with statistical significance defined as a p-value ≤ 0.05.

Results

Among the 244 patients with ESKD undergoing dialysis, 105 individuals (43.03%) were identified as having PEW. Multivariable logistic regression analysis indicated that female sex (adjusted odds ratio [AOR] = 2.30; 95% confidence interval [CI]: 1.33–3.98; p = 0.003) and age over 60 years (AOR = 3.30; 95% CI: 1.90–5.72; p < 0.001) were significant risk factors associated with PEW in this population.

Conclusion

Protein-energy wasting (PEW) was commonly observed among individuals with ESKD undergoing dialysis, with a higher prevalence noted in women and older adults. These results emphasize the necessity of implementing regular screening and prompt management strategies to address PEW in this patient group, with the goal of enhancing health outcomes and overall well-being.

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