ASSOCIATION OF ETIOLOGY WITH SUBOPTIMAL CORRECTION IN SEVERE HYPONATREMIA: A RETROSPECTIVE COHORT STUDY

 

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https://storage.unitedwebnetwork.com/files/1099/60cb8da484ae1e73336c6e33cd897221.pdf
ASSOCIATION OF ETIOLOGY WITH SUBOPTIMAL CORRECTION IN SEVERE HYPONATREMIA: A RETROSPECTIVE COHORT STUDY

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Akira
Nakamura
Akira Nakamura aki.aki.helloo@gmail.com Keio University School of Medicine Division of Nephrology, Endocrinology, and Metabolism, Department of Internal Medicine Tokyo Japan *
Takashin Nakayama takashin.nakayama@gmail.com Keio University School of Medicine Division of Nephrology, Endocrinology, and Metabolism, Department of Internal Medicine Tokyo Japan -
Tatsuhiko Azegami t.azegami-1114@keio.jp Keio University School of Medicine Division of Nephrology, Endocrinology, and Metabolism, Department of Internal Medicine Tokyo Japan -
Motoaki Komatsu mkomatsu0821@gmail.com Tokyo Saiseikai Central Hospital Department of Nephrology Tokyo Japan -
Kaori Hayashi kaorihayashi@keio.jp Keio University School of Medicine Division of Nephrology, Endocrinology, and Metabolism, Department of Internal Medicine Tokyo Japan -
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In the management of hyponatremia, achieving an appropriate rate of serum sodium correction is essential but remains challenging. The correction rate is thought to vary depending on the underlying etiology; however, how this influences the risk of suboptimal correction has not been fully elucidated. To address this knowledge gap, we aimed to evaluate whether the risk of inadequate correction differs across etiological categories in patients with severe hyponatremia.

This retrospective observational study included patients with severe hyponatremia, defined as a serum sodium level ≤120 mEq/L, identified either at admission or during hospitalization in two tertiary care centers between January 2014 and June 2024. Patients were classified into nine etiological categories: kidney losses, non-kidney losses, syndrome of inappropriate antidiuresis (SIAD), adrenal insufficiency, low solute intake, polydipsia, heart failure, cirrhosis, and kidney disease. The association between etiological categories and the incidence of rapid (≥10 mEq/L) or slow (≤5 mEq/L) sodium correction within the first 24 hours was assessed using logistic regression analysis.

Among 876 patients included in the analysis, the median (interquartile range) age was 73 (62–82) years. The baseline serum sodium level was 118 (115–119) mEq/L, and the 24-hour correction rate was 4.8 (1.7–7.8) mEq/L. Logistic regression analysis demonstrated that, compared with SIAD, polydipsia (odds ratio [OR], 10.3; 95% confidence interval [CI], 4.81–22.0), adrenal insufficiency (OR, 5.32; 95% CI, 2.29–12.4), non-kidney losses (OR, 3.25; 95% CI, 1.38–7.66), and low solute intake (OR, 3.15; 95% CI, 1.73–5.76) were significantly associated with rapid correction. In contrast, cirrhosis (OR, 2.24; 95% CI, 0.92–5.49), heart failure (OR, 1.79; 95% CI, 0.84–3.83), and kidney losses (OR, 1.48; 95% CI, 0.86–2.55) were related to slow correction. 

Correction rates varied according to the underlying etiology of severe hyponatremia. Careful assessment of etiology may help predict correction patterns and guide safer, more effective management strategies.

Kewords