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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Minimal change nephrotic syndrome (MCNS) is generally regarded as highly responsive to treatment; however, adult patients typically require a longer duration to achieve remission compared to pediatric cases. A cohort study involving Japanese patients demonstrated a correlation between the remission induction period and relapse in adult-onset MCNS, highlighting the clinical importance of this period. Despite this, few studies have investigated steroid responsiveness in adult-onset MCNS, and its defining characteristics remain unclear. Here, we analyzed the relationship between the remission induction period and various factors and examined the clinical characteristics of adult-onset MCNS patients at our hospital.
We retrospectively reviewed 33 Japanese adult patients (55 [43 – 73] year-old, 13 males) with newly diagnosed idiopathic MCNS confirmed by renal biopsy and clinical data, treated at a single center between April 2011 and September 2022. Following renal biopsy performed immediately after admission, all patients were empirically treated with glucocorticoids. Time to complete response (CR) was defined as the interval from treatment initiation to the reduction of urinary protein to less than 0.3 g/day (equivalent to <0.3 g/gCr), in accordance with JSN clinical guidelines for nephrotic syndrome.
Baseline characteristics of the 33 patients were as follows: systolic and diastolic blood pressures of 122 ± 16 mmHg and 72 ± 13 mmHg, respectively; eGFR of 60 ± 27 mL/min/1.73 m²; serum albumin of 1.7 ± 0.6 g/dL; and urinary protein of 12.5 ± 6.5 g/gCr. The mean time to CR was 15 ± 8 days. Patients classified as late responders (time to CR>14 days) were significantly older (p < 0.05), had lower eGFR (p<0.001), and lower serum IgM levels (p<0.05) compared to early responders. In a multiple linear regression model with time to CR as the dependent variable and age, eGFR, and log(IgM) as independent variables, an inverse relationship between time to CR and log(IgM) was confirmed, alongside the influence of other factors such as eGFR. Log-rank analysis of cumulative remission rates demonstrated that both renal function decline (eGFR<60 mL/min/1.73 m²) and the low-IgM group (IgM<121 mg/dL) were associated with significantly longer times to CR. For the classification of early versus late responders, the inclusion of eGFR and IgM variables improved model discrimination, as evidenced by an increase in the area under the curve from 0.738 to 0.823.
The present study indicates that eGFR and serum IgM levels at initial presentation may serve as useful predictors of time to remission in adult-onset MCNS. It is well established that abnormalities in immunoglobulin fractions arise from B-cell dysfunction in MCNS. These pathological alterations may influence steroid responsiveness independently of age and renal function.
