DESCRIPTIVE CHARACTERESTICS, PRESENTATION, ETIOLOGIES AND OUTCOME OF RENAL INFARCTION: A SYSTEMATIC REVIEW AND META-PROPORTIONAL ANALYSIS

 

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DESCRIPTIVE CHARACTERESTICS, PRESENTATION, ETIOLOGIES AND OUTCOME OF RENAL INFARCTION: A SYSTEMATIC REVIEW AND META-PROPORTIONAL ANALYSIS

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Hicham
Cheikh Hassan
Mariam Nour Eldine mariam.noureldine@lau.edu Lebanese American University School of Medicine Beirut Lebanon -
Hala Kilani hala.kilani@lau.edu.lb Lebanese American University School of Medicine Beirut Lebanon -
Patrick Hallak ph27@aub.edu.lb American University of Beirut Department of Nephrology and Hypertension Beirut Lebanon -
Sola Aoun Bahous sola.bahous@lau.edu.lb Lebanese American University School of Medicine Beirut Lebanon -
Siba Kallab siba.kallab@lau.edu.lb Lebanese American University School of Medicine Beirut Lebanon -
Karumathil M Murali Karumathil.Murali@health.nsw.gov.au Wollongong Hospital Renal Department Wollongong Australia - University of Wollongong Graduate School of Medicine Wollongong Australia
Hicham Cheikh Hassan h.s.hassan@gmail.com Lebanese American University School of Medicine Beirut Lebanon * University of Wollongong Graduate School of Medicine Wollongong Australia
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Renal infarction is rare and present with diverse symptoms. This may cause misdiagnosis, lead to delays in diagnosis and treatment. In order to better understand this rare disease, and to appreciate the possible impact on future outcomes we conducted a systematic review and meta-analysis of the literature to determine: 1) incidence and prevalence of renal infarction 2) patient baseline characteristics and symptoms 3) causes and 4) outcomes following renal infarction including death, progressing to chronic kidney disease (CKD) or dialysis. 

Web of science, PubMed and Scopus databases (upto November 2024) were searched for cohort studies with renal infarction patients. Articles were screened and data extracted independently by 2 authors. Data extraction included demographics, comorbidities, symptoms on presentation, causes and long-term outcomes. The pooled prevalence of the captured data was determined by a random effects meta-proportional analysis to yield a proportion and 95% confidence interval (95%CI). Heterogeneity was examined through I2. 

Out of 4,010 studies screened, 33 retrospective cohort studies were included, comprising 1 total of 12,824 patients with renal infarction. Study sample sizes ranged from 7 to 10,496 patients. Only 3 studies examined incidence, with a pooled analysis of 4.9 per 100,000 patient-years (95%CI 1.7- 9.7). Prevalence was examined in 6 studies (0.016%, 95%CI 0.08- 0.028, I2= 99%). The pooled mean age was 59 years (95%CI 56.3- 61.8; I2=95.0%) and the proportion of males was 0.61 (95%CI 0.58- 0.63, I2=47%). Comorbidity burden was high, with hypertension being the most prevalent (0.47, 95%I 0.43- 0.51) followed by atrial fibrillation (0.38, 95%CI 0.31-0.46), diabetes (0.16, 95%CI 0.12-0.20) and CKD (0.15, 95%CI 0.07- 0.27). Anticoagulation was being used by a third of patients on presentation (0.29, 95%CI 0.25-0.34). The most common symptom was flank and abdominal pain (0.77, 95%CI 0.66-0.85) but other presentations included fever, haematuria, proteinuria and acute kidney injury. An extra-renal infarction was detected in 0.18 (95%CI 0.15-0.22) of cases.

The commonest cause of renal infarction was cardiac (0.43, 95%CI 0.33- 0.52) of which atrial fibrillation was the most common (0.36, 0.27- 0.52). Other causes were hypercoagulable state (0.11, 95%CI 0.08- 0.14), renal artery damage (0.10, 95%CI 0.05- 0.17), trauma (0.04, 95%CI 0.01-0.07) and other/idiopathic (0.31, 95%CI 0.21-0.42). 

Pooled prevalence of acute dialysis on presentation was 0.04 (95%CI 0.02- 0.07). CKD developed in 0.23 (95%CI 0.16-0.31) while kidney failure requiring dialysis developed in 0.04. The pooled prevalence of inpatient mortality was 0.05 (95%CI 0.03-0.08) while long term mortality was higher (0.15, 95%CI 0.10-0.22) . 


Renal infarction is an uncommon condition with variable and often non-specific presentations. Cardiac sources, especially arterial fibrillation, are the leading causes though upto one-third of cases remain idiopathic. Sequalae following renal infarction can be significant including developing CKD and mortality. All studies were retrospective cohorts. Future studies should focus on unifying definitions, aiming to examine a larger population, of prospective design and focus on long term outcomes after the diagnosis. 

Kewords